ArticleFrontiers in cardiovascular medicine2025
CT predicts intraprocedural hemodynamics with computational fluid dynamics in TMVR-ineligible patients undergoing M-TEER.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hemodynamic outcomes in patients undergoing transcatheter mitral edge-to-edge repair (M-TEER) are difficult to predict. Computational fluid dynamics (CFD) is frequently used in biomedical engineering to simulate blood flow patterns under various conditions. Objectives: We developed a standardized workflow for individualized CFD analyses to predict postinterventional mitral valve gradients and residual regurgitation following TEER. Methods: Twenty patients with severe mitral regurgitation (MR) from two high-volume centers underwent full-cycle cardiac computed tomography before intervention. Based on the specific valve morphology, individualized CFD simulations were performed to calculate MR volumes prior to intervention and estimate hemodynamics after M-TEER. Results: CFD analyses (mean age 80 ± 4 years, 55% male) showed excellent correlation between baseline proximal isovelocity surface area (PISA)-based MR volumes, median 40 ml [interquartile range (IQR): 30-49 ml], and CFD-based calculation, median 30 ml (IQR: 27-54 ml; Conclusions: This is the first study to use a standardized CFD workflow for MR evaluation in patients undergoing TEER. In the future, CFD-based analyses may serve as a key diagnostic tool for procedural planning of TEER.
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