ArticleTranscranial magnetic stimulation (2024)2025
Chronic caffeine consumption on clinical TMS outcomes: A naturalistic retrospective analysis.
Article in Transcranial magnetic stimulation (2024), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
3 authors.
Funding
Abstract
Health and behavioral factors likely influence repetitive transcranial magnetic stimulation (rTMS) effectiveness, though clear support is lacking. Since habitual caffeine use has been found to impair corticomotor plasticity, we hypothesized that clinical benefits may likewise be impaired. We performed a retrospective analysis (n = 179) from the McLean Hospital TMS Clinic to explore the effect of self-reported caffeine use on TMS clinical outcomes. Self-report depression and anxiety scales from caffeine users and non-users were compared with Wilcoxon-rank-sum test and response and remission rates with chi-square; Spearman's was used to correlate correlation caffeine quantity with degree of clinical change. Both groups experienced a significant reduction in depressive symptoms as expected. Contrary to our hypothesis, however, we found no differences between caffeine users and non-users in total symptom reduction or response and remission rates, nor did we find a relationship between caffeine quantity and clinical change. This naturalistic analysis suggests that chronic caffeine consumption does not influence treatment outcomes in clinical rTMS for depression.
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