Evidence map›Paper›PMID 41346482›Full record

ArticleCase reports in ophthalmology

Long-Term Eplerenone Treatment in Peripapillary Pachychoroid Syndrome: A Case Series.

Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Giovanni Alessio, Francesco Boscia

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alba Chiara TermiteDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Pasquale ViggianoDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Giacomo BosciaDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Giovanni AlessioDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.
Francesco BosciaDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of the study was to evaluate the long-term efficacy of eplerenone in patients with peripapillary pachychoroid syndrome (PPS), a recently described entity characterized by vascular congestion of Haller's layer vessels near the optic nerve. Case Presentations: Three male patients (mean age: 70.3 years) with PPS received oral eplerenone 50 mg daily for 12 months. Baseline and post-treatment choroidal thickness, visual acuity, and retinal fluid status were assessed. At baseline, mean choroidal thickness was 420 µm, and mean visual acuity was 70 letters. After 12 months of treatment, all patients showed a significant reduction in choroidal thickness (mean: 48 µm, Conclusions: Long-term eplerenone treatment appears effective in reducing choroidal thickness and improving visual outcomes in PPS patients. These findings suggest mineralocorticoid receptor antagonists may be valuable in managing pachychoroid spectrum disorders.

Indexed as

Choroidal thicknessEplerenoneOptic disc edemaPachychoroid disease spectrumPeripapillary pachychoroid syndrome

Identifiers

PMID41346482
PMCPMC12674667

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