Evidence map›Paper›PMID 41346471›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Advances in electrical stimulation for wound healing.

Xiaofei Bi, Xiangchen Chen, Zheng Pang, Bihan Song, Hongxiang Li, Sicheng Feng, Hehe Jiang, Linlin Zhang, Haixiao Hu

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaofei BiCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xiangchen ChenSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Zheng PangInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Bihan SongCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hongxiang LiCollege of Health, Shandong University of Traditional Chinese Medicine, Jinan, China.
Sicheng FengCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Hehe JiangInstitute of Pharmacy (Institute of TCM Health Industrial Technology), Shandong University of Traditional Chinese Medicine, Jinan, China.
Linlin ZhangInstitute of Pharmacy (Institute of TCM Health Industrial Technology), Shandong University of Traditional Chinese Medicine, Jinan, China.
Haixiao HuSchool of Materials Science and Engineering, Qilu University of Technology (Shandong Academy of Science), Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical stimulation (ES), as a cutting-edge biomedical strategy for promoting wound healing, accelerates tissue regeneration and repair processes through directional electric field intervention. Research demonstrates that both endogenous weak bioelectric potentials and exogenously applied electric fields can effectively guide cellular migration along electric field gradients while activating the biological activities of fibroblasts, keratinocytes, and endothelial cells. These mechanisms enhance collagen synthesis and accelerate angiogenesis, thereby significantly improving wound closure rates. This review comprehensively examines recent advancements in ES technology for wound healing, focusing on emerging applications of active microcurrent devices, passive microcurrent systems, and electroactive wound dressings. Particular emphasis is placed on innovative applications of conductive polymers (CPs) and nanocomposite materials in wound repair. By systematically analyzing the underlying mechanisms and therapeutic applications of ES in wound healing, this work aims to provide novel perspectives for optimizing ES technologies and facilitating their clinical translation, offering both theoretical significance and practical value in regenerative medicine.

Indexed as

angiogenesiscell proliferationelectrical stimulationtherapeutic deviceswound healing

Identifiers

PMID41346471
PMCPMC12672508

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.