Evidence map›Paper›PMID 41346466›Full record

ArticleBrain communications2025

Eomesodermin-expressing CD4 Th cells and association with multiple sclerosis progression and brain atrophy.

Marielena Bongert, Emelie Schönauer, Paulina Trendelenburg, Ulas Ceylan, Theodoros Ladopoulos, Katja Vohl, David Bratek, Annika Mattukat, Léon Beyer, Klaus Gerwert and 7 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marielena BongertDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Emelie SchönauerDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Paulina TrendelenburgDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Ulas CeylanDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Theodoros LadopoulosDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Katja VohlDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
David BratekDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Annika MattukatDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Léon BeyerCenter for Protein Diagnostics (ProDi), Biospectroscopy, Ruhr-University Bochum, Bochum 44801, Germany.
Klaus GerwertCenter for Protein Diagnostics (ProDi), Biospectroscopy, Ruhr-University Bochum, Bochum 44801, Germany.
Takashi YamamuraDepartment of Immunology, National Institute of Neuroscience, NCNP, Tokyo 187-8502, Japan.
Carsten LukasInstitute of Neuroradiology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Ingo SchmitzDepartment of Molecular Immunology, Ruhr-University Bochum, Bochum 44801, Germany.ORCID https://orcid.org/0000-0002-5360-0419
Ruth SchneiderDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.ORCID https://orcid.org/0000-0002-0997-2725
Ilya AyzenbergDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Ralf GoldDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.
Simon FaissnerDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum 44791, Germany.ORCID https://orcid.org/0000-0002-3412-762X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis is a chronic inflammatory disease affecting the central nervous system. While treatment made huge advances, progression remains a challenge. Eomesodermin

Indexed as

biomarkermultiple sclerosisneuroprotectionprogressionT cells

Identifiers

PMID41346466
PMCPMC12673330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.