Evidence map›Paper›PMID 41346465›Full record

ArticleBrain communications2025

Elevated glioma-related cortical glutamate

Bodiabaduge Ashan P Jayasekera, Jehill Parikh, Tamara Modebadze, Anderson Brito Da Silva, Renae J Stefanetti, John Crossman, Damian Holliman, Mohammed A Hussain, Alistair Jenkins, Otto Major and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Bodiabaduge Ashan P JayasekeraBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0001-5953-3117
Jehill ParikhNewcastle Magnetic Resonance Centre, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, NE4 5PL, UK.
Tamara ModebadzeBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Anderson Brito Da SilvaTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0003-2764-5178
Renae J StefanettiWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0001-6402-6435
John CrossmanDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Damian HollimanDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Mohammed A HussainDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Alistair JenkinsDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Otto MajorDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Patrick MitchellDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Claire NicholsonDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Nicholas RossDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Dorothy WallaceNewcastle Magnetic Resonance Centre, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, NE4 5PL, UK.
Louise WardNewcastle Magnetic Resonance Centre, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, NE4 5PL, UK.
Tim HodgsonNewcastle Magnetic Resonance Centre, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, NE4 5PL, UK.
Mark R BakerTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0001-6916-1329
Gráinne S GormanWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Andrew BlamireNewcastle Magnetic Resonance Centre, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, NE4 5PL, UK.ORCID https://orcid.org/0000-0002-8749-1257
Mark O CunninghamDiscipline of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-7389-9569
Christopher J A CowieDepartment of Neurosurgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.ORCID https://orcid.org/0000-0003-0439-2278
Fiona E N LeBeauBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID https://orcid.org/0000-0003-1453-4022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas are the most common type of malignant brain tumour and are frequently associated with seizures. Seizures associated with gliomas are frequently refractory to conventional antiseizure medications and constitute a significant cause of morbidity. There is a clear need for a biomarker that will guide resection of the ictogenic areas during neurosurgical procedures to improve seizure control, limit morbidity and achieve better tumour clearance. Several studies have investigated glutamate in the peri-tumoural region using magnetic resonance spectroscopy (MRS), but findings remain inconclusive regarding the association among elevated glutamate, tumour type and seizure history. Furthermore, it is not known if high cortical glutamate would lead to spontaneous interictal discharges (IIDs)

Indexed as

electrophysiologyepilepsyglioma

Identifiers

PMID41346465
PMCPMC12674171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.