ArticleFrontiers in aging neuroscience2025
Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Clinical heterogeneity of Pisa syndrome across Lewy body disorders: a multicenter comparison of Parkinson's disease and dementia with Lewy bodies.Frontiers in aging neuroscience · 2026Article
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8 authors.
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Abstract
Background: Pisa syndrome (PS), characterized by trunk lateral flexion, remains rarely reported in dementia with Lewy bodies (DLB). While its pathogenesis is multifactorial, underlying mechanisms are not fully understood. Given the established link between postural control and cognition in aging populations, cognitive impairment has been implicated in PS development. Notably, no studies have investigated the potential contributions of cognitive dysfunction and neuropsychiatric symptoms to the development of PS in DLB patients or its relationship with caregiver burden. Methods: This study included 35 DLB patients with PS and 183 DLB patients without PS. We compared cognitive function across different domains using the Montreal Cognitive Assessment (MoCA) and its subdomains, and the Clock Drawing Test (CDT), and dementia severity using the Clinical Dementia Rating (CDR). The prevalence and severity of neuropsychiatric symptoms and caregiver distress were measured using the Neuropsychiatric Inventory (NPI) and Zarit Burden Interview (ZBI). Results: The patients in the PS group showed significantly worse performances in attention ( Conclusion: Our study reveals that PS in DLB is associated with specific deficits in attention and visuospatial/executive function, alongside more severe neuropsychiatric symptoms. These findings highlight the need for comprehensive management targeting both postural control and neuropsychiatric issues to alleviate caregiver burden. Future longitudinal studies are warranted to clarify the causal nature of these relationships.
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