ArticleFrontiers in aging neuroscience2025
Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical heterogeneity of Pisa syndrome across Lewy body disorders: a multicenter comparison of Parkinson's disease and dementia with Lewy bodies.Frontiers in aging neuroscience · 2026Article
- Altered cognitive performance is associated with auditory cortex functional connectivity in patients with unilateral sensorineural hearing loss.Frontiers in neuroscience · 2026Article
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7 authors.
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Abstract
Objective: To characterize abnormal functional connectivity in dementia with Lewy bodies (DLB) and its association with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Sixty-eight DLB patients and 38 age-, sex-, and education-matched healthy controls underwent neuropsychological assessments (MoCA, MMSE) and rs-fMRI. Imaging analyses included seed-based functional connectivity (sFC), independent component analysis (ICA), regional homogeneity (ReHo), fractional amplitude of low-frequency fluctuations (fALFF), and graph-theoretical network metrics (small-worldness, global/local efficiency). Results: DLB patients exhibited significantly reduced FC in the default mode network (DMN) and visual network, including PCC-AG ( Conclusion: DLB is characterized by DMN and visual network dysfunction, disrupted local neural activity, and impaired global network integration. These rs-fMRI metrics may serve as potential biomarkers for cognitive deficits in DLB.
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