Evidence map›Paper›PMID 41346426›Full record

ArticleOpen research Europe2024

The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease.

Ana Claudia Zenclussen, Valentina Belmar Erilkin, Linda Böhmert, Petra Borilova Linhartova, Albert Braeuning, Georg Braun, Cécile Chevrier, Liesbeth Duijts, Beate Isabella Escher, Janine Felix and 31 more

Abstract readLetter
In one paragraph

Article in Open research Europe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Ana Claudia ZenclussenDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.ORCID https://orcid.org/0000-0003-3544-4552
Valentina Belmar ErilkinEuropean Institute for Biomedical Imaging Research (EIBIR), Vienna, Austria.
Linda BöhmertGerman Federal Institute for Risk Assessment (BfR), Dept. Food Safety, Berlin, 10589, Germany.
Petra Borilova LinhartovaRECETOX, Faculty of Science, Masaryk University, Brno, South Moravian Region, Czech Republic.ORCID https://orcid.org/0000-0003-0953-3615
Albert BraeuningGerman Federal Institute for Risk Assessment (BfR), Dept. Food Safety, Berlin, 10589, Germany.
Georg BraunDepartment of Cell Toxicology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.ORCID https://orcid.org/0000-0002-2513-9039
Cécile ChevrierUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.
Liesbeth DuijtsDepartment of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Beate Isabella EscherGerman Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany.
Janine FelixDepartment of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Sergio Gómez-OlarteDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.ORCID https://orcid.org/0000-0002-9494-068X
Mònica GuxensInstitute for Global Health, ISGlobal, Barcelona, Spain.ORCID https://orcid.org/0000-0002-8624-0333
Gunda HerberthDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.ORCID https://orcid.org/0000-0003-0212-3509
Klara HilscherovaRECETOX, Faculty of Science, Masaryk University, Brno, South Moravian Region, Czech Republic.
Jana KlanovaRECETOX, Faculty of Science, Masaryk University, Brno, South Moravian Region, Czech Republic.
Yvonne KohlFraunhofer Institute for Biomedical Engineering IBMT, Sulzbach, Germany.
Katharina KrischakEuropean Institute for Biomedical Imaging Research (EIBIR), Vienna, Austria.
Dominique Lagadic-GossmannUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.
Sophie LangouëtUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.ORCID https://orcid.org/0000-0002-0016-5425
Sabrina LlopEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Maria Jose Lopez-EspinosaEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Léa MaitreInstitute for Global Health, ISGlobal, Barcelona, Spain.
Corinne Martin-ChoulyUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.ORCID https://orcid.org/0000-0001-7493-0612
Nicole MeyerDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Marion OuidirUniversity Grenoble Alpes, Inserm U-1209, CNRS-UMR-5309, Environmental Epidemiology Applied to Development and Respiratory Health Team, Institute for Advanced Biosciences, Grenoble, France.ORCID https://orcid.org/0000-0001-6027-1484
Thi Anh Mai PhamDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.ORCID https://orcid.org/0000-0001-7963-8864
Claire PhilippatUniversity Grenoble Alpes, Inserm U-1209, CNRS-UMR-5309, Environmental Epidemiology Applied to Development and Respiratory Health Team, Institute for Advanced Biosciences, Grenoble, France.
Raymond PietersInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Marie-Laure Pinel-MarieUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.
Normand PodechardUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.
Tobias PolteDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Elliott PriceRECETOX, Faculty of Science, Masaryk University, Brno, South Moravian Region, Czech Republic.
Oliver RobinsonMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Kristin SchubertDepartment of Molecular Toxicology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Anne SchumacherDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Violeta StojanovskaDepartment of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Tamara TalDepartment of Ecotoxicology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Saxony, 04318, Germany.
Paolo VineisMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Robert van VorstenboschInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Charline WarembourgUniv Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail - UMR_S 1085, Rennes, France.ORCID https://orcid.org/0000-0003-2716-9167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. ENDOMIX takes a novel approach to identifying associations and causality between EDCs and adverse health outcomes by focusing on exposure to mixtures of EDCs over the life course, including windows of susceptibility, using human biomonitoring data from several European cohorts. We will model and measure how real-life EDC mixtures act together and target the immune system to initiate, trigger or maintain disease. Health effects will be investigated using pioneering methodologies ranging from high-throughput

Indexed as

chemical mixturesEDC exposureendocrine disrupting chemicalsimmune systeminterdisciplinary approachlong-term health effectsscience to policy translation

Identifiers

PMID41346426
PMCPMC12673258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.