ArticleBiological psychiatry global open science2025
Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Background: Major depressive disorder (MDD) is heterogeneous, with diverse risk pathways leading to illness. Identifying causal routes to depression helps prioritize targets for early intervention and prevention strategies. Although irritability is associated with risk for later depression, this association could be explained by confounders, including genetic confounders. Methods: We used two genetically informed designs to examine whether irritability is causally linked to depression. First, using data from the Child and Adolescent Twin Study in Sweden (CATSS) ( Results: In CATSS, associations were observed between irritability at age 15 (parent-reported odds ratio [OR] = 1.93 [1.61-2.34], Conclusions: These results indicate that self-reported irritability may represent a causal risk pathway to MDD and thus could serve as a potential target for MDD prevention or early intervention.
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