ArticleFrontiers in cellular and infection microbiology2025
The role of cyano-phycocyanin as a quorum sensing inhibitor to attenuate
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: In recent years, developing drugs that directly target pathways related to the pathogenic mechanisms of bacteria has been a research hotspot, and quorum sensing (QS) is one of the most effective strategies to combat multidrug-resistant bacteria. We evaluated the inhibitory effect of cyano-phycocyanin (C-PC) on the virulence of PA2 Methods: In this study, the minimum inhibitory concentration (MIC) and growth curve of C-PC on PA2 were determined, and the effect of C-PC on QS-regulated virulence factors and the anti-biofilm activity of C-PC against PA2 were investigated. The Results: C-PC attenuated biofilm formation, pyocyanin synthesis, motility, and PQS signaling molecule production. Moreover, C-PC significantly downregulated the transcription levels of QS-related genes in PA2, including Conclusion: Taken together, these results suggest that C-PC showed strong anti-QS activity, providing new insights into the development of strategies against PA infection.
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