Evidence map›Paper›PMID 41346362›Full record

Observational studyFrontiers in cellular and infection microbiology2025

Longitudinal assessment of oral and gut microbiome overlap in patients with Alcohol Use Disorder undergoing inpatient treatment.

Jennifer J Barb, Alexandria N Hughes, Shubhi Nanda, Ralph Thadeus S Tuason, Gwenyth R Wallen, Katherine A Maki

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02231840 (NIAAA Natural History Protocol), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02231840 recruitingnot on this map

NIAAA Natural History Protocol

TypeobservationalSponsorNational Institute on Alcohol Abuse and Alcoholism (NIAAA)Ran2015 to 2044Enrolled7,500ConditionsAlcohol Use Disorder
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer J BarbTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Alexandria N HughesTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Shubhi NandaTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Ralph Thadeus S TuasonTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Gwenyth R WallenTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Katherine A MakiTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol Use Disorder (AUD) is a condition associated with compulsive alcohol consumption and disruption across multiple physiological systems. This brief report builds on previously published research separately examining longitudinal changes in the oral and gut microbiomes of treatment-seeking individuals with AUD. Twenty-two participants diagnosed with severe AUD were enrolled in an inpatient treatment protocol (NCT02231840) and provided oral and stool samples over 28 days (goal 10 samples/participant). The aim of this brief report was to explore within-person overlap and compositional similarity of the oral and gut microbiomes at the genus level, using the Sorenson-Dice Index and Robust Aitchison Distance. Results indicated that the oral and gut microbiomes became less similar during the first week of treatment, with both the number of shared genera and Sorenson-Dice Index values decreasing significantly (

Indexed as

AlcoholismGastrointestinal MicrobiomeMouthAdultBacteriaFecesFemaleHumansInpatientsLongitudinal StudiesMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SAitchisonalcohol use disorderAUDgut microbiomeoral microbiome

Identifiers

PMID41346362
PMCPMC12672516

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.