ArticleAnales del sistema sanitario de Navarra2025
[Langerhans cell histiocytosis diagnosed in mediastinal lymph nodes by endoscopic ultrasound-guided fine-needle aspiration].
Article in Anales del sistema sanitario de Navarra, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 57-year-old male smoker underwent endobronchial ultrasound-guided fine-needle aspiration due to increased radiotracer uptake on positron emission tomography. The cytopathologist prepared in situ smears for immediate (Diff-Quick) and definitive (Papanicolaou) evaluation. Solid tissue fragments and blood clots were used to create a cell block processed as a biopsy. Cytological analysis revealed histiocytic cells with clefted nuclei expressing CD68, CD1a, Langerin, and S100, along with a numerous eosinophils, establishing the diagnosis of Langerhans cell histiocytosis. Accurate cytological identification of this entity in mediastinal lymph nodes remains a significant diagnostic challenge. This case underscores the importance of the cytopathologist´s active involvement in sample handling during the procedure to optimize material performance, enabling the use of ancillary techniques required for a comprehensive diagnosis, avoiding more aggressive diagnostic approaches.
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