ArticleMovement disorders : official journal of the Movement Disorder Society2026
Delayed Disease Onset Report in UK Biobank: Implications for Prodromal Studies in Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Risk Factors for the Diagnosis of Progressive Supranuclear Palsy in the UK Biobank.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Plasma neurofilament light chain as a predictor of multiple system atrophy in idiopathic REM sleep behavior disorder.Journal of neurology · 2025Article
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Authors and funding
16 authors.
Funding
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Abstract
backgroundUK Biobank (UKBB) provides extensive genetic, imaging, and health data for ~500,000 participants, enabling studies of prodromal phases of diseases like Parkinson's disease (PD). However, during analysis, we became concerned about the accuracy of diagnosis timing.
objectiveTo evaluate the accuracy of PD diagnosis timing in UKBB.
methodsWe examined PD diagnosis timing using hospital, primary care, death records, and self-reported data. We assessed discrepancies between sources and identified co-occurring diagnoses recorded on the same date as PD.
resultsAmong 3979 PD cases, 97% of the 786 participants with both self-reported and electronic health records (EHRs) reported their diagnosis earlier than recorded in the EHR, with a typical delay of 5 to 7 years. Multiple codiagnoses were often logged on the same date, suggesting retrospective or batch data entry.
conclusionsSubstantial delays in PD documentation may misclassify already diagnosed individuals as prodromal. This introduces significant bias into studies of early disease markers and distorts the timing between risk factors and clinical onset. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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