Trial reportBMC oral health2025
Histological evaluation of vital full pulpotomy techniques in permanent mature teeth with symptomatic irreversible pulpitis using three calcium silicate cements: a randomized controlled trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regenerative Potential of Biodentine in Complex Endodontic Conditions: A Systematic Review of Clinical and Radiological Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Direct Clinical Evidence of Long-term Hard-tissue Repair after Miniature/Tampon Pulpotomy: An Accidental Re-entry Case after Six Years.Iranian endodontic journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to evaluate the histological response of mandibular mature premolars with symptomatic irreversible pulpitis (SIP) following cervical pulpotomy using three bioactive materials: Mineral Trioxide Aggregate (MTA), Biodentine, and TotalFill BC RRM. MATERIALS AND
methods40 young, healthy patients with 60 mandibular mature premolars with deep carious lesions, diagnosed with SIP and scheduled for orthodontic extraction, were included. Premolars were randomly assigned to three groups based on the bioactive material used during pulpotomy (MTA, Biodentine, or TotalFill BC RRM). Each group was divided into two subgroups according to the follow-up period: the first subgroup was extracted after 1 week, and the second after 6 months. Histological evaluations assessed pulpal inflammation, the degree of pulp disorganization, and dentinal-like bridge formation. Kruskal-Wallis and Wilcoxon tests were used to analyse the data. The significance level was set at α = 0.05.
resultsNo significant differences were observed among the bioactive materials in histological evaluations at the two time points (p > 0.005). Most samples exhibited an inflammatory response and marked histological disruption during the first week. Over the six-month follow-up period, inflammation and histological disruption decreased progressively compared with the one-week follow-up (p < 0.05). Moreover, a noticeable dentinal-like bridge was observed in most samples after six months, compared with the one-week follow-up (p < 0.001).
conclusionThe histological response following cervical pulpotomy with bioactive materials (MTA, Biodentine, and TotalFill BC RRM) in permanent mature teeth with SIP is comparable, indicating their similar effectiveness.
trial registrationThe trial protocol was registered retrospectively at the Registry of ISRCTN (Trial ID: ISRCTN16268487) on 17/03/2025.
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