ArticleJournal of neuroinflammation2025
NEO1 modulates the A1 astrocyte polarization in subarachnoid hemorrhage through the cPLA2-MAVS signaling pathway.
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Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Comorbid mechanisms of neuroinflammation and astrocytic ferroptosis in neurological disorders: A vicious cycle (Review).Biomedical reports · 2026Review
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20 authors.
Yu Wu *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Boyang Wei *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Lei Jin *Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Longxiang LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Zeyu YangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Can LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Jiaming ZhouNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Wenzhi GongNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Xin FengNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shenquan GuoNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Wenping ChengNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Ran LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shuyin LiangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shixing SuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Fa JinNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Xin ZhangNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Yanchao LiuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Chuanzhi DuanNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. doctor_duanzj@163.com.
Xifeng LiNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. nflxf@126.com.
Wenchao LiuNeurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. liuwenchao_zj@126.com.
Funding
China Postdoctoral Science Foundation 2025M772292Guangzhou Science and Technology Project SL2022A04J00214National Health Commission of the People's Republic of China GWJJQ2022100104National Natural Science Foundation of China 82001300National Natural Science Foundation of China 82271297National Natural Science Foundation of China 82271298
Abstract
Neuroinflammation following subarachnoid hemorrhage (SAH) plays a critical role in multiple pathological pathways and poor prognosis. Several studies have indicated that resting astrocytes can polarize into at least two distinct phenotypes following SAH, pro-inflammatory A1 phenotype and anti-inflammatory A2 phenotype. However, the specific polarization patterns of astrocytes after SAH have not been fully elucidated. Targeting A1 astrocytes after SAH may represents a promising strategy for mitigating neuroinflammatory and enhancing neurological recovery. Our single-cell RNA sequencing revealed an increase in A1 astrocytes after SAH. Furthermore, the data suggested that NEO1 may be involved in astrocyte polarization. Then, we generated astrocyte-specific NEO1 conditional knockout (cKO) mice by crossing NEO1
Indexed as
Adaptor Proteins, Signal TransducingAstrocytesCell PolarityPhospholipases A2, CytosolicSignal TransductionSubarachnoid HemorrhageAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingPhospholipases A2, CytosolicAstrocyte polarizationCPLA2MAVSNEO1NeuroinflammationSubarachnoid hemorrhage
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