Evidence map›Paper›PMID 41345787›Full record

ArticleCommunications biology2025

Intestinal adaptation to cold-induced metabolic demand and feeding requires GLP-1R and GLP-2R signalling.

Nadya M Morrow, Antonio A Hanson, Claire Fong-McMaster, Dawson B H Livingston, Hoda Osman, Lauren Hamilton, Natasha A Trzaskalski, Cassandra A A Locatelli, Mélodie N Bellefleur, Ethel Messika-Zeitoun and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nadya M Morrow *The University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Antonio A Hanson *The University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Claire Fong-McMasterThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Dawson B H LivingstonThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-7197-9146
Hoda OsmanThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Lauren HamiltonThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.ORCID http://orcid.org/0009-0006-3110-842X
Natasha A TrzaskalskiThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Cassandra A A LocatelliThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.ORCID http://orcid.org/0009-0005-9490-2121
Mélodie N BellefleurThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Ethel Messika-ZeitounThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Sebastian M CinoThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Serena M PulenteThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Iryna AbramchukThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-8314-0951
Xiaoling ZhaoThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Ilka Lorenzen-SchmidtThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Arianne MorissetteThe University of Ottawa Heart Institute, Ottawa, ON, Canada.
Krista A PowerThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Mary-Ellen HarperThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada.
Erin E MulvihillThe University of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, Ottawa, ON, Canada. emulvihi@uottawa.ca.ORCID http://orcid.org/0000-0002-3981-0241

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic cold exposure in mice increases metabolic demand and food intake; the gut correspondingly expands its absorptive surface area. Gut enteroendocrine cells produce peptide hormones including glucagon-like peptide-1 (GLP-1), GLP-2, and glucose-dependent insulinotropic polypeptide (GIP) in response to a meal to facilitate nutrient absorption and post-prandial metabolism. The requirement of GLP-1, GLP-2, and GIP receptor signaling for small intestinal adaptations to chronic cold stress has not been investigated. Here, we show that male and female wild-type, double incretin receptor knockout (Glp1r

Indexed as

Adaptation, PhysiologicalCold TemperatureGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-2 ReceptorReceptors, GlucagonAnimalsEatingFemaleGlucagon-Like Peptide 1Glucagon-Like Peptide 2MaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionGlp1r protein, mouseGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide 2Glucagon-Like Peptide-2 ReceptorReceptors, Glucagon

Identifiers

PMID41345787
PMCPMC12775481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.