Evidence map›Paper›PMID 41345753›Full record

ArticleDiscover mental health2025

Longitudinal assessment of brain volume and shape alterations in depressive patients with differential suicidality.

Vincent Chin-Hung Chen, Yuan-Hsiung Tsai, Gigin Lin, Che-Yu Hsu, Yi-Hsiang You, Jun-Cheng Weng

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In one paragraph

Article in Discover mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Vincent Chin-Hung ChenTai-An Hospital, Taichung, Taiwan.
Yuan-Hsiung TsaiDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Gigin LinDepartment of Medical Imaging and Intervention and Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan, Taiwan.
Che-Yu HsuDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33302, Taiwan.
Yi-Hsiang YouDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33302, Taiwan.
Jun-Cheng WengClinical Metabolomics Core Lab, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. jcweng@mail.cgu.edu.tw.

Funding

Chang Gung University NMRPD1N0291~3National Science and Technology Council MOST109-2314-B-182-047-MY3, NSTC112-2221-E-182-013-MY3
6 · The paper itself

Abstract

BACKGROUND AND

aimsIn recent years, the study of brain structural changes in individuals experiencing suicidal ideation and depression has attracted increasing interest. This study investigated changes in gray and white matter volumes among different groups. We recruited 86 patients, including 26 healthy controls (HCs), 29 with depression (NS), 18 with suicidal ideation (SI), and 13 improved (IM), to further understand the impact of treatment on suicidal ideation. MATERIALS AND

methodsWe used MRI to analyze four groups of participants at two time points over one-year intervals. Additionally, evaluations were conducted using clinical assessment scales (HAM-D, HADS-A, BSS, RRS).

resultsRepeated measures Analysis of Covariance (ANCOVA) and paired t tests revealed significant changes in brain volume across different groups at two time points. Notable differences were observed in regions such as the cingulate gyrus, corpus callosum, insula, amygdala, and hippocampus, indicating dynamic structural changes related to suicidal ideation and its treatment.

conclusionsOur findings highlight the potential value of brain structural changes in evaluating depression and suicidal ideation, supporting the effectiveness of early interventions in improving mental health. The observed alterations in gray and white matter emphasized the importance of targeted treatments for better patient outcomes.

Indexed as

Clinical assessmentCognitive functionDepressionDifferential suicidalityLongitudinal study

Identifiers

PMID41345753
PMCPMC12678688

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