Evidence map›Paper›PMID 41345739›Full record

ArticleDiagnostic and prognostic research2025

Explainable AI in healthcare: to explain, to predict, or to describe?

Alex Carriero, Anne de Hond, Bram Cappers, Fernando Paulovich, Sanne Abeln, Karel Gm Moons, Maarten van Smeden

Abstract readLetter
In one paragraph

Article in Diagnostic and prognostic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Audience-Customized Translation of Rule-Based Evidence with Large Language Models Across Multiplexer Benchmarks.Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alex CarrieroJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. a.j.carriero@umcutrecht.nl.
Anne de HondJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bram CappersDepartment of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
Fernando PaulovichDepartment of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
Sanne AbelnDepartment of Information and Computing Sciences, Utrecht University, Utrecht, The Netherlands.
Karel Gm MoonsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maarten van SmedenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Explainable Artificial Intelligence (AI) methods are designed to provide information about how AI-based models make predictions. In healthcare, there is a widespread expectation that these methods will provide relevant and accurate information about a model's inner-workings to different stakeholders (ranging from patients and healthcare providers to AI and medical guideline developers). This is a challenging endeavor since what qualifies as relevant information may differ greatly depending on the stakeholder. For many stakeholders, relevant explanations are causal in nature, yet, explainable AI methods are often not able to deliver this information. Using the Describe-Predict-Explain framework, we argue that Explainable AI methods are good descriptive tools, as they may help to describe how a model works but are limited in their ability to explain why a model works in terms of true underlying biological mechanisms and cause-and-effect relations. This limits the suitability of explainable AI methods to provide actionable advice to patients or to judge the face validity of AI-based models.

Identifiers

PMID41345739
PMCPMC12679721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.