Evidence map›Paper›PMID 41345738›Full record

ArticleVeterinary research2025

METTL14 protects sheep small intestinal epithelial cells against Escherichia coli F17 infection by influencing the PI3K-Akt signaling pathway.

Qi Li, Weihao Chen, Yanjun Duan, Huiguo Yang, Kai Quan, Xiang Chen, Xiaoyang Lv, Wei Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Weihao ChenCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Yanjun DuanCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Huiguo YangInstitute of Animal Husbandry, Xinjiang Academy of Animal Sciences, Urumqi, 830013, China.
Kai QuanCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economics, Zhengzhou, 450046, China.
Xiang ChenGuizhou Provincial Key Laboratory of Animal Genetics, Breeding and Reproduction, Guizhou University, Guiyang, 550025, China.
Xiaoyang LvJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education, Yangzhou University, Yangzhou, 225009, China. dx120170085@yzu.edu.cn.
Wei SunCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. dkxmsunwei@163.com.

Funding

Jiangshu 333 Distinguished Talents Project Foundation (2022) 2-323Jiangsu Agricultural Science and Technology Innovation Fund CX (23)1036Jiangsu graduate research and practice innovation project SJCX25_2380National Natural Science Foundation of China-CGIAR 32061143036Natural Science Foundation of the Jiangsu Higher Education Institutions of China 22KJA230001Project of Jiangsu Innovation Support Programme for International Science and Technology Cooperation - "Belt and Road" Innovation Cooperation BZ2023009Yangzhou Meat Sheep Industry Public Service Platform YZ2023222
6 · The paper itself

Abstract

Escherichia coli F17 is emerging as one of the main causes of bacterial diarrhea in sheep. After lambs are infected, the bacteria colonize the small intestinal epithelial cells (IECs) through adhesion of F17 fimbriae. This colonization triggers the release of enterotoxins, disrupting the intestinal mucosa and resulting in symptoms such as diarrhea. These pathological effects contribute to considerable global economic losses and continuously impact the economic development of the sheep farming industry. Meanwhile, m

Indexed as

Escherichia coli InfectionsMethyltransferasesSheep DiseasesAnimalsEpithelial CellsEscherichia coliIntestinal MucosaIntestine, SmallPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSheepSignal TransductionMethyltransferasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktEscherichia coli F17METTL14sheep diarrhea

Identifiers

PMID41345738
PMCPMC12687527

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.