Evidence map›Paper›PMID 41345728›Full record

ArticleEuropean journal of medical research2025

Prevalence of treatment outcomes and associated factors of diabetic ketoacidosis among adult diabetic patients admitted to Debre Markos comprehensive specialized hospital, northwest Ethiopia.

Fenta Limenih, Feriehiwot Molla, Muluken Teshome, Melesse Belayneh Yayeh

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Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Fenta LimenihDepartment of Curative and Rehabilitative Service Core Process, Dembecha Distric Health Office, Dembecha, Ethiopia.
Feriehiwot MollaDepartment of Public Health, School of Public Health, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Muluken TeshomeDepartment of Public Health, School of Public Health, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Melesse Belayneh YayehDepartment of Public Health, School of Public Health, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia. meleseyayeh@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic ketoacidosis emergencies are serious acute complications of diabetes mellitus, and their health and economic impacts have been increasing among adult diabetic patients. Despite the growing burden of emergencies from diabetic ketoacidosis among adults with diabetes, its outcomes and factors of treatment have not been well studied in Ethiopia.

objectiveTo assess the prevalence of poor treatment outcomes of diabetic ketoacidosis and associated factors among adult diabetic patients admitted to the Debre Markos comprehensive specialized hospital, northwest Ethiopia.

methodsA hospital-based retrospective cohort study was conducted at Debre Markos comprehensive specialized hospital from April 8, 2025 to April 28, 2025. A total of 360 patients with diabetic DKA who were admitted from August 28, 2019 to September 30, 2024 participated in the study. A simple random sampling technique was used to select study participants. Data were extracted using a pre-tested data collection tool adapted from different literatures. The data were entered into epi-data version 4.6.0 and exported to SPSS version 26 for analysis. Both bivariable and multivariable binary logistic regression analysis were done. Statistical significance was declared at a p-value < 0.05 with an odds ratio of 95% confidence interval.

resultsThe prevalence of poor treatment outcomes was 15.5% (95%, CI: 11.5%, 19.3%). Factors, such as severe DKA (AOR: 1.482, 95% CI: 1.324, 4.872), the presence of comorbidities (AOR: 1.752, 95% CI: 1.215, 3.865), and underlying infections (95% CI: 1.362, 4.125), discontinuation of drugs (AOR: 2.115, 95% CI: 1.245, 3.865), treatment complications (AOR: 1.356, 95% CI: 1.253, 4.125), ketone levels > 3 (AOR: 1.213, 95% CI: 1.052, 2.876), and hospital stays of less than 5 days (AOR: 1.29, 95% CI: 1.022, 3.254) were also significant factors associated with poor outcomes in patients with DKA.

conclusionsThis study found that a high number of patients with DKA in the Debre Markos comprehensive specialized hospital experienced poor treatment outcomes. Significant factors included severe DKA, comorbidities, infections, drug discontinuation, treatment complications, high ketone levels and short hospital stays. To improve treatment outcomes, early identification and proactive management of high-risk DKA patients, particularly those who present with severe illness, comorbidity conditions, or infections, shall be prioritized.

Indexed as

Diabetic KetoacidosisAdultAgedEthiopiaFemaleHospitalizationHospitals, SpecialHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsTreatment OutcomeYoung AdultAssociated factorsDiabetic ketoacidosisEthiopiaHospitalPoor treatment outcome

Identifiers

PMID41345728
PMCPMC12781682

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