Evidence map›Paper›PMID 41345695›Full record

ReviewChinese medicine2025

The role and therapeutic advances of neutrophils in acute myocardial infarction: from traditional chinese medicine modulation to modern therapeutic strategies.

Yisha Wan, Junping Zhang, Yingxi Yang

Abstract readReview
In one paragraph

Review in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yisha WanNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine , Beijing University of Chinese Medicine, Beijing, 100029, China.
Junping ZhangDepartment of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin, 300193, China.
Yingxi YangTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. yangyingxi@tjutcm.edu.cn.

Funding

National Natural Science Foundation of China 82204965
6 · The paper itself

Abstract

Acute Myocardial Infarction (AMI) is one of the leading causes of global mortality, posing a severe threat to human health. Currently, the clinical management of AMI remains a major challenge, and its pathological mechanisms lack systematic elucidation. Neutrophils, as key effector cells in the pathogenesis of AMI, have emerged as a highly promising therapeutic target. This review comprehensively summarizes the origin, subtypes, stage-specific roles, and mechanistic contributions of neutrophils in AMI. Furthermore, it explores how active components of traditional Chinese medicine (TCM) modulate neutrophil function through multi-target interventions, exerting therapeutic effects in anti-inflammation, anti-fibrosis, and pro-angiogenesis. Recent advances highlight significant progress in neutrophil-targeted therapies, including novel drug development, nanoparticle-based delivery systems, and multi-omics biomarker discovery, offering new avenues for precision medicine in AMI. Although translational challenges persist, enhanced collaboration between basic research and clinical applications may unlock innovative treatment strategies for AMI patients.

Indexed as

Acute myocardial infarctionMechanism of actionNeutrophilsTraditional Chinese medicine

Identifiers

PMID41345695
PMCPMC12679801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.