ArticleJournal of translational medicine2025
Enhancing buccal mucosa graft healing in urethroplasty: unraveling the molecular effects of two distinct therapies: low-dose radiation and low-intensity shockwave therapy.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Benign Uroandrological Ecosystem: A Thorough Overview from Single-Cell and Spatial Transcriptomics.Research (Washington, D.C.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundBuccal mucosa graft (BMG) urethroplasty is the gold standard for urethral stricture repair; nevertheless, graft failure remains challenging because of inadequate vascularization, excessive fibrosis and a dysregulated immune response. Low-dose ionizing radiation (LDIR) and low-intensity shockwave therapy (LiSWT) modulate angiogenesis, inflammation and tissue remodeling. However, their impact on BMG healing remains unexplored. This study aimed to assess the effects of LDIR and LiSWT applied separately on BMG integration, with a focus on vascularization, fibrosis, immune modulation and epithelial remodeling.
methodsWistar Han IGS rats underwent urethral stricture induction followed by BMG urethroplasty. Animals were assigned to separate treatment groups receiving either LDIR (0.3 Gy) administered on postoperative days 2–5 or LiSWT (500 impulses, EFD: 0.160 mJ/mm²) applied on days 0, 7 and 14. Graft area perfusion was measured via laser Doppler imaging over time. Histology and spatial transcriptomics were performed on day 21 to assess vascularization, fibrosis, epithelial remodeling, inflammation and molecular signatures.
resultsLDIR significantly increased graft perfusion (mean + 68% and + 73% on postoperative days 7 and 14) and vessel density (mean + 81% at day 21), while both therapies markedly reduced fibrosis (mean − 68% with LDIR and − 64% with LiSWT). This study provides the first spatial transcriptomic analysis of BMG healing under LDIR or LiSWT, revealing distinct therapy-specific regenerative signatures at day 21: LDIR upregulated angiogenic pathways, whereas LiSWT primarily promoted epithelial remodeling and differentiation. Insights remain limited to the selected time point (day 21), which may not reflect the entire healing trajectory.
conclusionsWhen applied independently, LDIR and LiSWT improve BMG integration by improving vascularization and immune modulation while reducing fibrosis, addressing major causes of urethroplasty failure. Their potential as perioperative adjuncts to enhance graft survival and functional recovery, including erectile outcomes, warrants further clinical investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.