Observational studyJournal of neuroinflammation2025
Infection-driven proteomic signatures in immune cell-derived extracellular vesicles reflect hemorrhagic stroke outcome.
Observational study in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAnalyzing the content of immune cell-derived extracellular vesicles (EVs) may reveal biomarkers that elucidate the mechanisms through which infection negatively affects outcomes in patients with intracerebral hemorrhage (ICH).
methodsA prospective observational study in patients with acute ICH classified by the occurrence of in-hospital infection within 7 days and outcomes at 6 months, good outcome defined as an improvement of > 10 points or > 50% in NIHSS score and a mRS score 0–2. Immune cell-derived EVs were obtained from blood samples at 7 days by immunoprecipitation with anti-CD3 (T cells), anti-CD20 (B cells) and anti-CD14 (monocytes) antibodies. The protein content of the EVs was analyzed by data independent acquisition mass spectrometry. Differential abundance between groups was defined as fold-change ≥ 2 or ≤ 0.5 and p ≤ 0.05.
resultsThe study enrolled 44 patients: 17 (39%) infected, 14 (82%) with poor outcomes, and 27 (61%) with no infection, 12 (44%) with poor outcomes. There were 190 proteins with differential abundance in the EVs of infected patients, 6 relevant proteins associated with poor outcome and infection: in T cell-derived EVs PSME1 (involved in apoptosis), H2B1C and MTREX (involved in transcription regulation, DNA replication and DNA repair) were more abundant; in B cell-derived EVs, COHA1 (organization of extracellular matrix) was less abundant; and in monocyte-derived EVs, PCSK9 (cholesterol metabolism) and CMC1 (energy-related metabolic pathways) were less abundant.
conclusionsA cluster of proteins in immune system-derived EVs are involved in key biological pathways potentially linked to infection-related poor outcomes in patients with ICH.
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