Evidence map›Paper›PMID 41345607›Full record

ArticleBMC cancer2025

Glioma-related epilepsy in patients with newly diagnosed and recurrent glioblastoma, IDH-wildtype: a study under the 2021 WHO CNS tumor classification.

Xing Fan, Jianli Dai, Jiajia Liu, Gan You, Ke Li, Shengyu Fang, Jiahan Dong, Jiawei Shi, Jiangwei Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xing Fan *Beijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China. xingkongyaoxiang@163.com.
Jianli Dai *Institute of New Materials and Advanced Manufacturing, Beijing Academy of Science and Technology, Beijing, 100089, China.
Jiajia LiuBeijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China.
Gan YouDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Ke LiBeijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China.
Shengyu FangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Jiahan DongBeijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China.
Jiawei ShiBeijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China.
Jiangwei WangBeijing Neurosurgical Institute, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, Fengtai District, 10070, China.

Funding

Beijing Natural Science Foundation L256058Beijing Research Ward Excellence Program BRWEP2024W032040209
6 · The paper itself

Abstract

backgroundThe 2021 classification of central nervous system tumors significantly alters the defined category of glioblastoma (GBM). This study aims to evaluate the clinical relevance of glioma-related epilepsy (GRE) in patients with the newly classified GBM, IDH-wildtype.

methodsA single-center retrospective cohort study was performed. The correlation of GRE with clinicopathological features was explored via appropriate inter-group statistical methods. Kaplan-Meier analysis was employed to assess the prognostic value of preoperative GRE with respect to overall survival (OS) and progression-free survival (PFS). Multivariate binary logistic regression analysis was carried out to identify potential risk factors associated with inadequate seizure control.

resultsThe final cohort included 294 patients. Preoperative GRE was observed in 22.4% of newly diagnosed and 19.7% of recurrent GBM cases. In patients with newly diagnosed GBM, GRE was significantly associated with younger age (p < 0.001). Moreover, survival analysis confirmed the prognostic significance of preoperative GRE for improved OS and PFS (p = 0.012 and 0.004, respectively) in the same population. Moreover, in newly diagnosed GBM cases, preoperative GRE was identified as the independent risk factor for inadequate postoperative seizure control (OR 4.009, 95% CI 1.447–11.106, p = 0.008).

conclusionThe current study comprehensively describes the clinical correlations of GRE in GBM, IDH-wildtype. The incidence of preoperative GRE in GBM patients is approximately 20%. Among patients with newly diagnosed GBM, IDH-wildtype, preoperative GRE is more likely to occur in younger individuals and is associated with prolonged survival outcomes. Furthermore, a history of preoperative GRE may increase the risk of inadequate postoperative seizure control in this population.

Indexed as

Brain NeoplasmsEpilepsyGlioblastomaNeoplasm Recurrence, LocalAdultAgedFemaleHumansIsocitrate DehydrogenaseKaplan-Meier EstimateMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsIDH1 protein, humanIsocitrate DehydrogenaseGlioblastomaGlioma-related epilepsySeizure controlSurvival outcomes

Identifiers

PMID41345607
PMCPMC12797526

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