Evidence map›Paper›PMID 41345591›Full record

ArticleBMC infectious diseases2025

A severe Clostridioides difficile ribotype 027 infection in Beijing, China, july 2024.

Xinfei Chen, Yang Chen, Han Zhang, Wen Shi, Houpeng Wong, Jin Li, Ziyue Zhou, Feiyi Liu, Yiying Zhao, Yingchun Xu and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinfei Chen *Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yang Chen *Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Han Zhang *Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Wen ShiDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Houpeng WongGraduate School, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Jin LiDepartment of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Ziyue ZhouDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Feiyi LiuDepartment of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yiying ZhaoDepartment of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Yingchun XuDepartment of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. xycpumch@139.com.
Meng XiaoDepartment of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. cjtcxiaomeng@aliyun.com.

Funding

National High-Level Hospital Clinical Research Funding 2022-PUMCH-A-058National Key Research and Development Program of China 2022YFC2303002
6 · The paper itself

Abstract

backgroundClostridioides difficile ribotype (RT) 027 is particularly virulent, capable of causing severe conditions such as ileus, toxic megacolon, hypotension, or shock. Outbreaks of RT027 C. difficile are more frequently reported abroad compared to China.

methodsWe present a case of toxic megacolon caused by an RT027 C. difficile infection and trace the source of the infectious agent using whole genome sequencing. The agar dilution approach was utilized to determine antimicrobial susceptibility.

resultsPhylogenetic analysis demonstrated that the origin of this isolate was located in the same bifurcating branch of strains previously isolated in Beijing in 2012, yet it clusters within a new subcluster. The single nucleotide polymorphism (SNP) differences between this strain and other isolates from mainland China range from 1 to 16, and the SNP differences between mainland China strains and international strains within the FQR1 lineage range from 7 to 37.

conclusionsThe emergence of hypervirulent RT027 C. difficile necessitates an accurate tracing of its source. Whole genome sequencing can aid in precisely identifying origins. Although RT027 C. difficile remains primarily sporadic in China, enhanced surveillance of C. difficile and stringent hospital infection control measures is imperative.

Indexed as

Clostridioides difficileClostridium InfectionsAnti-Bacterial AgentsBeijingChinaHumansMicrobial Sensitivity TestsPhylogenyPolymorphism, Single NucleotideRibotypingWhole Genome SequencingAnti-Bacterial AgentsClostridioides difficileRibotype 027Whole-genome sequencing

Identifiers

PMID41345591
PMCPMC12781333

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