Evidence map›Paper›PMID 41345567›Full record

ReviewBMC neurology2025

Central pontine myelinolysis in diffuse large B-cell lymphoma, a case series and literature review.

Ahmed Bakharji, Ali Al Hijab, Talal Al Harbi, Eman Nasim Ali, Husam Almuhaish, Mariam Eskander, Manar Abdulbaqi, Shahid Bashir, Ibtisam Al Thubaiti

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed BakharjiNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Ali Al HijabNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Talal Al HarbiNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Eman Nasim AliNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Husam AlmuhaishNeuroradiology Section, Medical Imaging Service Center, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia.
Mariam EskanderNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Manar AbdulbaqiNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Shahid BashirNeurology Department, Neuroscience Center, King Fahad Specialist Hospital- Dammam, Dammam, Saudi Arabia.
Ibtisam Al ThubaitiDepartment of Neurology, King Fahad Military Medical Complex Dhahran, Dhahran, Eastern Region, Saudi Arabia. dr.althubaiti@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma in Saudi Arabia. Osmotic demyelination syndrome (ODS) is divided into central pontine myelinolysis (CPM) and extrapontine myelinolysis. The occurrence of osmotic demyelination syndrome is classically described in the setting of rapid correction of hyponatremia. Clinical Manifestations are variable, ranging from asymptomatic cases to quadriparesis and locked-in syndrome in the severe form.

methodWe reported a total of six cases with diffuse large B-cell lymphoma (DLBCL) that developed central pontine myelinolysis. A literature review was done reviewing all case reports of central pontine myelinolysis occurring in patients with non-Hodgkin lymphoma.

resultsA total of 16 patients were reviewed, including our six cases and ten patients from published reports. Nine out of 16 were asymptomatic (56.3%), and DLBCL was present in all cases except one (93.8%). Risk factors such as fluctuations in osmolality or hypoalbuminemia were documented in 9 out of the 16 cases (65.3%), and none had undergone overly rapid sodium correction. The outcome was favorable in all cases, with no residual neurological deficits.

conclusionDLBCL can predispose to pontine changes suggestive of CPM with a relatively favorable prognosis. The nature of these changes remains uncertain due to lack of histopathological confirmation.

Indexed as

Lymphoma, Large B-Cell, DiffuseMyelinolysis, Central PontineAdultFemaleHumansMaleMiddle AgedYoung AdultCentral pontine myelinolysisDiffuse large B-cell lymphomaNon-Hodgkin lymphoma

Identifiers

PMID41345567
PMCPMC12797817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.