ArticlePediatric research2026
Fetal inflammatory response severity on placental histology identifies neonates at risk for meconium aspiration syndrome.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Reassessing vigabatrin in infantile spasms: clinical risks, mechanistic insights, and future directions.Pediatric research · 2026Article
- Two sides of the same coin: distinguishing the role of fetal versus maternal placental pathology on brain injury of prematurity.Pediatric research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile fetal hypoxia-ischemia is a known trigger for meconium aspiration syndrome (MAS), many infants develop MAS without it, suggesting other risk factors. We examined the association between MAS and the presence and severity of fetal inflammatory response (FIR) on placental histopathology. METHODS/STUDY
designA single-center retrospective cohort study of term infants with meconium-stained amniotic fluid (MSAF) born at Parkland Hospital (2010-2018). Maternal and infant demographics and clinical data were recorded. Placental histopathologic evidence of FIR was classified per Amsterdam criteria. MAS was defined as respiratory distress in an infant with MSAF requiring NICU admission and ≥48 hours of respiratory support and/or radiographic findings of MAS.
resultsAmong 1,696 term neonates with MSAF, 118 (6.9%) developed MAS. Univariate analysis showed that MAS was associated with post-term delivery, non-reassuring fetal heart patterns, cesarean delivery, thick meconium, low Apgar scores, severe acidosis, and presence of FIR (all P < 0.001). On multivariate analysis, FIR remained significant (adjusted OR 2.50, 95% CI 1.41-4.82). Moderate to severe FIR conferred 5-times higher odds for developing MAS (adjusted OR 5.43, 95% CI 2.83-10.40).
conclusionFIR, particularly its severity, is an independent predictor of MAS, highlighting intrauterine inflammation as a key mechanism alongside hypoxia-ischemia. IMPACT: Fetal Inflammatory Response (FIR) is independently associated with Meconium Aspiration Syndrome (MAS) Increasing severity of FIR confers progressively higher risk of MAS. This is the first study to demonstrate a dose-response relationship between FIR severity on MAS. These observations highlight the role of intrauterine inflammation in MAS pathogenesis and provide new insight into its impact on term neonates.
Indexed as
Identifiers
41345334What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.