Evidence map›Paper›PMID 41345244›Full record

ArticleNPJ precision oncology2025

Collaborative framework on responsible AI in LLM-driven CDSS for precision oncology leveraging real-world patient data.

Sonja Mathes, Dyke Ferber, Tobias Dreyer, Kai J Borm, Luise Modersohn, Theresa Willem, Richard Dirven, Julien Vibert, Simon Kreutzfeldt, Raquel Perez-Lopez and 7 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sonja MathesTUM School of Medicine and Health, Department of Dermatology, Technical University of Munich, Munich, Germany. sonja.mathes@mri.tum.de.
Dyke FerberElse Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.
Tobias DreyerTUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.
Kai J BormTechnical University of Munich, School of Medicine and Health, Department of Radiation Oncology, Munich, Germany.
Luise ModersohnTUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.
Theresa WillemTUM School of Medicine and Health, Institute of History and Ethics in Medicine, Technical University of Munich, Munich, Germany.
Richard DirvenDepartment of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Julien VibertCancer Core Europe, Villejuif, France.
Simon KreutzfeldtCancer Core Europe, Villejuif, France.
Raquel Perez-LopezCancer Core Europe, Villejuif, France.
Arsela PrelajCancer Core Europe, Villejuif, France.
Fredrik StrandDepartment of Oncology and Pathology, Karolinska Institutet, Solna, Sweden.
Richard D BairdCancer Core Europe, Villejuif, France.
Martin BoekerTUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.
Jakob Nikolas KatherElse Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.
Maximilian TschochoheiTUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.
Jacqueline LammertTUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision oncology leverages real-world data, essential for identifying biomarkers and therapies. Large language models (LLMs) can aid at structuring unstructured data, overcoming current bottlenecks in precision oncology. We propose a framework for responsible LLM integration into precision oncology, co-developed by multidisciplinary experts and supported by Cancer Core Europe. Five thematic dimensions and ten principles for practice are outlined and illustrated through application to uterine carcinosarcoma in a thought experiment.

Identifiers

PMID41345244
PMCPMC12796327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.