Evidence map›Paper›PMID 41345148›Full record

ArticleScientific reports2025

Comprehensive chemical profiling and bioactivity assessment of Porodaedalea pini and Phellinus tremulae.

Grzegorz Świderski, Monika Kalinowska, Ewa Zapora, Marek Wołkowycki, Marcin Stocki, Ewa Ciszkowicz, Aleksandra Bocian, Marcin Jaromin, Mirosław Tyrka, Katarzyna Lecka-Szlachta and 5 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Grzegorz ŚwiderskiDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, Białystok, 15-351, Poland. g.swiderski@pb.edu.pl.
Monika KalinowskaDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, Białystok, 15-351, Poland.
Ewa ZaporaDepartment of Silviculture and Forest Utilization, Bialystok University of Technology, Wiejska 45E, Bialystok, 15-351, Poland.
Marek WołkowyckiDepartment of Silviculture and Forest Utilization, Bialystok University of Technology, Wiejska 45E, Bialystok, 15-351, Poland.
Marcin StockiDepartment of Silviculture and Forest Utilization, Bialystok University of Technology, Wiejska 45E, Bialystok, 15-351, Poland.
Ewa CiszkowiczDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy 6, Rzeszow, 35-959, Poland.
Aleksandra BocianDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy 6, Rzeszow, 35-959, Poland.
Marcin JarominDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy 6, Rzeszow, 35-959, Poland.
Mirosław TyrkaDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy 6, Rzeszow, 35-959, Poland.
Katarzyna Lecka-SzlachtaDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstańców Warszawy 6, Rzeszow, 35-959, Poland.
Renata ŚwisłockaDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, Białystok, 15-351, Poland.
Małgorzata ZawadzkaDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, Białystok, 15-351, Poland.
Marzena SmolewskaDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, Białystok, 15-351, Poland.
Małgorzata PawłowskaFaculty of Environmenal Engineering and Energy, Lublin University of Technology, Nadbystrzycka 40B, Lublin, 20-618, Poland.
Paweł GolianekFaculty of Environmenal Engineering and Energy, Lublin University of Technology, Nadbystrzycka 40B, Lublin, 20-618, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fruiting bodies of the fungi Porodaedalea pini (Brot.) Murrill and Phellinus tremulae (Brot.) A. Ames were collected in the Białowieża Forest (Poland). Morphological identification of the collected fruiting bodies was carried out and genetic tests were performed to confirm the identity of the collected specimens. Methanol extracts for biological activity tests were prepared. The methanolic extracts obtained had a plastic consistency, high viscosity and colors from brown to dark brown. The determination of selected elements in Phellinus extracts was performed by X-ray spectrofluorimetry. Thermal decomposition studies and spectroscopic analysis of the dry fruiting bodies were performed. The content of active substances was examined using GCMS chromatography. GCMS analysis showed that the extracts of the tested species contain many chemical compounds that are characterized by high antioxidant potential. These include, among others, phenolic acids (caffeic acid, p-coumaric acid, ferulic acid, 3-hydroxybenzoic acid). In the extract of P. pini, the content of phenolic acids is higher than in P. tremulae. The P. tremulae extract (83.70+/-1.00%) possesses similar antiradical activity against DPPH• as P. pini extract (80.00+/-0.58%). The extracts were tested for their antimicrobial activity against multi-resistant bacteria. Cytotoxic activity was also tested. Both extracts inhibited the growth of S. aureus 4459 (MIC = 6.25 mg/ml), the clinical strain resistant to erythromycin. Cytotoxicity assessment showed that only the P. tremulae extract significantly decreased HaCaT cell viability by 37% and 42% at concentrations of 400 and 800 µg/ml, respectively.

Indexed as

Anti-Bacterial AgentsAntioxidantsBasidiomycotaFruiting Bodies, FungalGas Chromatography-Mass SpectrometryHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntioxidantsAntimicrobial studyCytotoxic studyMedicinal fungiPhellinus tremulaePorodaedalea pini

Identifiers

PMID41345148
PMCPMC12678438

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.