Evidence map›Paper›PMID 41345109›Full record

ArticleCell death discovery2025

GSDMD deficiency attenuates BPD by suppressing macrophage pyroptosis and promoting M2 polarization.

Xinyi Yang, Xinru Wang, Yihang Yang, Yue Ma, Xinli Liu, Dandan Mo, Chunbao Guo, Wenli Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinyi Yang *School of Pharmacy, Chongqing Medical University, Chongqing, PR China.
Xinru Wang *School of Pharmacy, Chongqing Medical University, Chongqing, PR China.
Yihang Yang *Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, PR China.
Yue MaDepartment of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, PR China.
Xinli LiuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, PR China.
Dandan MoDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, PR China.
Chunbao GuoDepartment of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, PR China.
Wenli HanSchool of Pharmacy, Chongqing Medical University, Chongqing, PR China. hanwenli@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-6312-4815

Funding

National Natural Science Foundation of China (National Science Foundation of China) No. 81900001Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) CSTB2022NSCQ-MSX0819Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) Grant No. CSTB2024NSCQ-LZX0109Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) No.CSTB2019JCYJ-MSXMX0189
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD), a frequent complication in preterm infants receiving supplemental oxygen, is characterized by hyper-activation of macrophage inflammasomes, exuberant release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), and Gasdermin D (GSDMD)-driven pyroptosis. However, the precise contribution of macrophage pyroptosis to BPD pathogenesis remains incompletely defined, and effective pharmacological interventions are still lacking. Using neonatal C57BL/6 wild-type (WT) and GSDMD-knockout (GSDMD

Identifiers

PMID41345109
PMCPMC12824217

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.