ArticleNature communications2025
Hierarchical crack-resistant, tissue-mimetic hydrogels enabled by progressive nanocrystallization of anisotropic polymer networks.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Strengthening Constitutive Motifs in Isotropic Fibrous Hydrogel for Exceptional Damage Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Trainable Hydrogels: Mechanistic Principles, Training Strategies, and Frontier Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Compliance for Resistance: The Intrinsic Extraordinary Isotropic Anti-Fatigue Performance of Fish Bladder.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ultrastrong and Tough Anisotropic Organogel via Alignment-Induced Densification and Glycerol Plasticization.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bio-Ionic Liquid-Induced Rapid Self-Initiating Tough Ionogels for In Situ Adhesion.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Multi-scale structural engineering enables ultra-strong and tough eutectogels.Nature communications · 2026Article
- Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels.Materials horizons · 2026Article
- Poly(Vinyl Alcohol)-Saccharide Hydrogels with Size-Tunable Plasticization-to-Reinforcement for Flexible Sensors.Gels (Basel, Switzerland) · 2026Article
- Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management.Biomaterials research · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Addressing the persistent challenge of reconciling extreme mechanical robustness with tissue-mimetic functionality in hydrogels, we present a phase-transition-guided hierarchical engineering strategy that progressively architectures anisotropic polyvinyl alcohol networks through sequential mechanical training, wet-annealing, and salting-out. This triphasic processing induces programmable structural evolution: (1) mechanical training aligns polymer chains, (2) wet-annealing relaxes the stress while stabilizes oriented crystallites through solvent-plasticized rearrangement, and (3) salting-out densifies the network via chain aggregation and hydrogen-bond proliferation. The resultant hierarchical architecture achieves high fatigue resistance (threshold: 2083 J·m
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.