Evidence map›Paper›PMID 41344323›Full record

ArticleCell reports. Medicine2025

Frontoparietal network mediates the antidepressant effects of accelerated iTBS and cTBS: TMS-EEG study.

Xianwei Che, Haoyang Zhao, Xinyi Ye, Shaoyong Ye, Zhen Zhen, Zhimin Huang, Ying Li, Shiyi Zhang, Pengfeng Xu, Xuanqiang Chen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xianwei CheDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China; Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Haoyang ZhaoDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Xinyi YeDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Shaoyong YeDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Zhen ZhenCentre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Zhimin HuangCentre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Ying LiDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Shiyi ZhangDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Pengfeng XuDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Xuanqiang ChenDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Chaonan JiangDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Fen PanDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Honglin LuanDepartment of Psychiatry, Wen Zhou Seventh People's Hospital, Wenzhou 325006, China.
Jingkai ChenDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Desheng ShangDepartment of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Shaohua HuDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China.
Yiheng TuCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Li HuCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Bernadette M FitzgibbonSchool of Medicine and Psychology, The Australian National University, Canberra, ACT, Australia; Monarch Research Institute, Monarch Mental Health Group, Sydney, NSW, Australia.
Paul B FitzgeraldSchool of Medicine and Psychology, The Australian National University, Canberra, ACT, Australia.
Robin F H CashDepartment of Psychiatry, The University of Melbourne, Parkville, VIC, Australia; Department of Biomedical Engineering, The University of Melbourne, Parkville, VIC, Australia.
Manli HuangDepartment of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100, China; Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China. Electronic address: huangmanli@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accelerated intermittent and continuous theta burst stimulation (a-iTBS and a-cTBS) show strong efficacy for treatment-resistant depression (TRD), yet their neural mechanisms remain unclear. This study uses concurrent transcranial magnetic stimulation (TMS) and electroencephalography (TMS-EEG) to examine these mechanisms in 40 TRD patients and 40 healthy controls (HCs). TRD individuals demonstrate abnormal local cortical excitability at baseline, characterized by left hypoactivity and right disinhibition. A-iTBS increases left excitability, and a-cTBS increases right inhibition, and both normalize it to the level of HCs. Network analyses reveal that a-iTBS improves current propagation to the left inferior parietal lobule (IPL), correlating with a better antidepressant effect. Contrastingly, a-cTBS induces a widespread inhibition as indicated by current propagation over parietal cortices, with the left IPL being most prominent, and this also correlates with a better antidepressant effect. These findings outline the frontoparietal circuitry in TMS antidepressant effects and provide insights for optimizing treatment efficacy. This study was registered at the Chinese Clinical Trial Registry (ChiCTR2200055320).

Indexed as

Depressive Disorder, Treatment-ResistantElectroencephalographyFrontal LobeNerve NetParietal LobeTranscranial Magnetic StimulationAdultAntidepressive AgentsFemaleHumansMaleMiddle AgedAntidepressive Agentsinferior parietal lobuletheta burst stimulationTMS-EEGtreatment-resistant depression

Identifiers

PMID41344323
PMCPMC12765827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.