Evidence map›Paper›PMID 41344265›Full record

ArticleNeoplasia (New York, N.Y.)2026

IFNβ-pSTAT1-IRF1 axis controls colorectal tumor development through induction of immunogenic Ly6C

Yan Li, Yanmin Wu, Liyan Liang, Xufeng Yao, Yiyang Pan, Lurong Zhang, Yaxin Wang, Jian Zhang, Kwan T Chow, Chunwan Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan LiSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Yanmin WuSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Liyan LiangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Xufeng YaoSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Yiyang PanSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Lurong ZhangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Yaxin WangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Jian ZhangAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Kwan T ChowDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, China.
Chunwan LuSchool of Life Sciences, Tianjin University, Tianjin 300072, China. Electronic address: chunwanlu@tju.edu.cn.

Funding

Guangdong Provincial Key Laboratory of Molecular Tumor PathologyNatural Science Foundation of China
6 · The paper itself

Abstract

It has been extensively studied that IFN-I inhibits tumor progression through their intrinsic functions in tumor cells, of which, regulating tumor cell immunogenicity is a critical way. Besides to tumor cells, myeloid cells also comprise a major component of tumor microenvironment. Nevertheless, whether IFN-I modulates the immunogenicity and function of myeloid cells in tumor microenvironment is less explored. In this research, we report that IFNβ effectively induces Ly6C

Indexed as

Antigens, LyColorectal NeoplasmsInterferon-betaInterferon Regulatory Factor-1Myeloid CellsSTAT1 Transcription FactorAnimalsCell DifferentiationCell Line, TumorDisease Models, AnimalHumansMiceSignal TransductionTumor MicroenvironmentAntigens, LyInterferon-betaInterferon Regulatory Factor-1Ly-6C antigen, mouseSTAT1 Transcription FactorIFNβImmunogenicityIRF1Ly6CNOS2STAT1

Identifiers

PMID41344265
PMCPMC12719569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.