Evidence map›Paper›PMID 41344055›Full record

ArticleTranslational oncology2026

Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells.

Chenxuan Zhang, Peng Wang, Jia Yu, Jianhui Yuan, Lilong Zhang, Man Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenxuan ZhangDepartment of hepatobiliary Surgery, Wuhan University, Renmin Hospital, Hubei Province, 238 Jiefang Road, Wuhan, Hubei Province, 430060, China; General Surgery Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Peng WangGeneral Surgery Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China; Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Jia YuDepartment of hepatobiliary Surgery, Wuhan University, Renmin Hospital, Hubei Province, 238 Jiefang Road, Wuhan, Hubei Province, 430060, China; General Surgery Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Jianhui YuanDepartment of hepatobiliary Surgery, Wuhan University, Renmin Hospital, Hubei Province, 238 Jiefang Road, Wuhan, Hubei Province, 430060, China; General Surgery Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Lilong ZhangDepartment of hepatobiliary Surgery, Wuhan University, Renmin Hospital, Hubei Province, 238 Jiefang Road, Wuhan, Hubei Province, 430060, China; General Surgery Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Man LiDepartment of hepatobiliary Surgery, Wuhan University, Renmin Hospital, Hubei Province, 238 Jiefang Road, Wuhan, Hubei Province, 430060, China. Electronic address: liman192@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The preference of cancer cells to generate energy from glycolysis for rapid cell proliferation is called the Warburg effect. Poly(ADP-ribose) polymerase 1 (PARP1) performs various cellular functions, including poly-ADP-ribosylation and DNA repair. In the present study, we investigated the novel effects and mechanisms of PARP1 inhibition on glucose metabolism in colorectal cancer cells under hypoxia. We subjected Caco-2 and LoVo cancer cell lines to a concentration gradient of PARP1 inhibitor in a hypoxic environment induced with a tri-gas incubator (5 % CO

Indexed as

Cell metabolismColorectal cancerNAD(+)/NADHPARP1Warburg effect

Identifiers

PMID41344055
PMCPMC12720136

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.