Evidence map›Paper›PMID 41343965›Full record

ArticleInternational dental journal2026

proBDNF-SorCS2 Axis Suppresses Osteogenesis and Augments Inflammation of Human Periodontal Ligament Stem Cells in Inflammatory Conditions.

Lifei Pan, Yao Yang, Xiangbin Jia, Rui Zhao, Yuting Wang, Xiaoyue Guan, Tiezhou Hou

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In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lifei PanKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yao YangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiangbin JiaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Rui ZhaoKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, Baoji Stomatological Hospital of Shaanxi, Baoji, China.
Yuting WangKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaoyue GuanKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: guanxy531@xjtu.edu.cn.
Tiezhou HouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xian Jiaotong University, Xi'an, Shaanxi, China; Department of Cariology and Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: tiezhou@mail.xjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPeriodontitis is a chronic inflammatory disease occurring in periodontal supporting tissues. Periodontal ligament stem cells (PDLSCs) are considered a promising source for periodontal regeneration and periodontitis treatment. Previous studies have shown that mature brain-derived neurotrophic factor (BDNF) can promote the multidirectional differentiation potential of PDLSCs. It has also been found that the proBDNF (precursor form of BDNF)-mediated signaling pathway is involved in immune-inflammatory diseases. In addition, some scholars have found that proBDNF and its receptor, sortilin-related central nervous system expressed receptor 2 (SorSC2), can induce cell apoptosis. However, the role of the proBDNF-SorCS2 axis in the development of periodontitis and its influence on human periodontal ligament stem cells (hPDLSCs) has not been elucidated. Our present experiment aims to investigate the relationship between the proBDNF-SorCS2 axis and periodontitis, as well as the role of proBDNF-SorCS2 in the osteogenic differentiation of hPDLSCs.

methodsIn this study, 30 patients with periodontitis (PD) and 30 healthy controls (Cont) were selected to detect the protein expression level and the distribution of the proBDNF-SorCS2 axis in periodontal tissues. In addition, an inflammatory model of hPDLSCs was established to study the regulation of SorCS2 expression on inflammation and cell osteoblastic differentiation.

resultsIn our experimental results, we found that the protein expressions of proBDNF and receptor SorCS2 were significantly increased in periodontitis tissues and colocalized with the hPDLSC surface marker CD90. Importantly, we found that the reduction of SorCS2 in hPDLSCs inhibited the protein activity of the proBDNF-SorCS2 signaling axis, IL-6, and IL-1β, promoting osteogenic differentiation of hPDLSCs. We also note that the proBDNF-SorCS2 signaling axis is involved in the activation of the JNK signaling pathway.

conclusionThe protein levels of both proBDNF and its receptor SorCS2 were significantly upregulated in periodontitis tissues and involved in regulating the inflammatory expression level and osteogenic differentiation of hPDLSCs. The proBDNF-SorCS2 axis represents a promising target for novel, localized therapeutic interventions in periodontitis. CLINICAL RELEVANCE: The current study provides a new theoretical perspective and information for the treatment of periodontitis.

Indexed as

Brain-Derived Neurotrophic FactorOsteogenesisPeriodontal LigamentPeriodontitisStem CellsAdultCase-Control StudiesCell DifferentiationCells, CulturedFemaleHumansInflammationMaleSignal TransductionBDNF protein, humanBrain-Derived Neurotrophic FactorOsteogenic differentiationPeriodontal ligament stem cellsPeriodontitisProBDNFSorCS2

Identifiers

PMID41343965
PMCPMC12719731

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