Evidence map›Paper›PMID 41343880›Full record

ArticleAmerican journal of surgery2026

Resected intrahepatic cholangiocarcinoma: Is adjuvant chemotherapy associated with improved overall survival?

R L Wolansky, M A Kendall, T Zander, J Sujka, P C Kuo, M S Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R L WolanskyUniversity of South Florida College of Medicine, Dept of Surgery, Tampa, FL, USA. Electronic address: rachelwolansky@usf.edu.
M A KendallUniversity of South Florida College of Medicine, Dept of Surgery, Tampa, FL, USA.
T ZanderUniversity of South Florida College of Medicine, Dept of Surgery, Tampa, FL, USA.
J SujkaUniversity of South Florida College of Medicine, Dept of Surgery, Tampa, FL, USA.
P C KuoUniversity of South Florida College of Medicine, Dept of Surgery, Tampa, FL, USA; Bay Pines Veteran's Hospital, Research and Development, Bay Pines, FL, USA.
M S BakerHuntsman Cancer Institute, University of Utah, Dept of Surgery, Salt Lake City, UT, USA.

Funding

Surgeon-Scientist Research Training in Injury Pathobiology and Outcomes In Critical IllnessT32GM144274 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI PAUL C KUO, Matthias Majetschak · 2023 to 2026
$635k
NIGMS NIH HHS T32 GM144274
6 · The paper itself

Abstract

backgroundRecent randomized trials evaluating survival benefit to adjuvant chemotherapy (AC) in cholangiocarcinoma evaluate heterogeneous populations including patients with gallbladder cancer, extrahepatic, and intrahepatic cholangiocarcinoma (ICCA). The efficacy of AC in ICCA remains undefined.

methodsWe queried the National Cancer Database for patients undergoing resection of localized ICCA between 2006 and 2017. Patients receiving AC were 1:1 propensity score matched for age, sex, race, comorbidities, insurance, stage, radiation, and resection margin to those undergoing resection alone. Kaplan-Meier (KM) methods were used to compare 5-year overall survival (OS) patterns for matched cohorts.

results1312 patients underwent resection of ICCA; 489 (37.3 ​%) received AC. 411 patients undergoing AC were successfully matched to 411 undergoing surgery alone. Median OS was 40.8 months for patients treated with AC versus 32.0 months for those undergoing resection alone (p ​= ​0.151).

conclusionsAC offers limited potential benefit to patients with resected ICCA.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaHepatectomyAgedChemotherapy, AdjuvantFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesSurvival RateUnited StatesAdjuvant chemotherapyIntrahepatic cholangiocarcinomaOverall survival benefit

Identifiers

PMID41343880
PMCPMC13647221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.