SynthesisPloS one2025
Oropouche infection in Peruvian patients: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Correction: Oropouche infection in Peruvian patients: A systematic review and meta-analysis.PloS one · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Oropouche virus (OROV), discovered in 1955, has evolved from being a pathogen limited to the Amazon basin to becoming a growing threat to public health in Latin America. Because its symptoms are similar to those of dengue and zika, diagnosis is complicated. In this context, the objective of this study is to determine the prevalence of epidemiological and clinical characteristics in Peruvian patients diagnosed with Oropouche.
methodsA systematic review and meta-analysis were performed in accordance with PRISMA guidelines. An exhaustive literature search was conducted up to April 10, 2025, across ten databases using MeSH terms like "Oropouche" and "Peru," combined with Boolean operators. Only observational studies conducted in Peru that reported confirmed OROV infections through reverse transcription polymerase chain reaction (RT-PCR) or enzyme-linked immunosorbent assay (ELISA), and that described clinical or epidemiological characteristics, were included. The methodological quality of these studies was evaluated using the JBI-MAStARI tool. To estimate the pooled prevalence and 95% confidence intervals, random-effects models were applied in R (version 4.2.3). Heterogeneity was assessed using the I² statistic, and publication bias was evaluated through funnel plots and Egger's test, when applicable.
resultsSix observational studies published between 2010 and 2020 were included, involving 396 Peruvian patients diagnosed with OROV by RT-PCR or ELISA. The studies were conducted in Piura, Loreto, Huánuco, Madre de Dios, and San Martín. Most patients were between 20 and 30 years old; 44.9% were male. All studies were of moderate quality. Due to the limited number of studies, publication bias was not assessed. The most common symptoms were fever, headache, myalgia, arthralgia, and retro-ocular pain.
conclusionThe findings of this study reveal a significant occurrence of diverse symptoms in Peruvian patients infected with OROV. Due to the clinical resemblance to other arboviruses, it is essential to establish more precise diagnostic methods to prevent misdiagnosis and underreporting. The existing evidence remains limited, highlighting the importance of enhancing epidemiological monitoring, improving diagnostic tools, and creating public health strategies specifically targeted at endemic regions to reduce the effects of this emerging infection.
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