ArticlePloS one2025
Bone Health Index (BoneXpert) and parameters of peripheral quantitative computed tomography indicate overall adequate bone health in adolescents with chronic endocrine diseases at time of transition.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimLow bone mass is common in children and adolescents with chronic endocrine disorders. Peripheral quantitative computed tomography (pQCT) is used to quantify bone health. A new automated Bone Health Index (BHI) determination (BoneXpertTM) is available using digitized X-rays of the left hand taken for bone age (Greulich&Pyle, BA) determination. In this study, we determine the BHI in adolescents with various endocrine disorders and compare it to conventional pQCT indices to evaluate the BHI as a potential surrogate parameter for bone health and muscle strength in adolescents.
methods134 adolescents (70 females) with chronic endocrine diseases and a median age of 17.6 years (IQR: 16.4,19.4) were included at the time of transition. Diagnoses were growth hormone deficiencies (GHD, n = 37), Turner syndrome (TS, n = 27), congenital adrenal hyperplasia (CAH, n = 22), small for gestational age (SGA, n = 20), multiple pituitary hormone deficiency (MPHD, n = 17) and Klinefelter syndrome (KS, n = 11). BA and BHI were assessed by BoneXpert™ (available for 104 patients) and were compared to a random subgroup with available pQCT parameters (n = 38: 13 CAH, 12 GHD, 7 TS and 6 SGA) assessed by XCT-2000 scanner. Further, grip strength was assessed by hand dynamometer (n = 134).
resultsMedian BHI-SDS for all patients available was -0.66 (IQR: -1.50,0.18, n = 104), lowest in patients with CAH (-1.04, IQR: -2.34,0.22, n = 22). The majority of patients (58.6%) had a BHI-SDS greater than -1, indicating adequate bone health. Median pQCT parameters and median grip strength showed a z-score greater than -1, suggesting an appropriate muscle strength for most patients. Patients with both available BHI-SDS and pQCT parameters (n = 32) showed significant positive correlations with several measurements: bone mineral content (65%) SDS (ρ = 0.576, p < 0.001); metaphyseal (4%) site total BMD SDS (ρ = 0.492, p = 0.005); total cross-sectional area SDS (ρ = 0.379, p < 0.032) and SSI SDS (ρ = 0.417, p = 0.018). In addition, BHI-SDS correlated positively with muscle cross-sectional area SDS (ρ = 0.352, p = 0.066, n = 32) and grip strength SDS (ρ = 0.205, p = 0.050, n = 104).
conclusionsAt the time of transition, the bone health of adolescents with chronic endocrine diseases is mostly appropriate, as estimated by BoneXpertTM and pQCT. Grip strength was also adequate in the majority of patients. In addition, this study is the first to demonstrate a significant correlation between these methods in adolescents. Consequently, the BHI has the potential to be an effective screening tool for assessing bone health, characterized by wide availability and low radiation exposure, though additional analyses are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.