Evidence map›Paper›PMID 41343181›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

Microbial dysbiosis alters serotonin signaling in a postinflammatory murine model of visceral pain.

Timothy D Roth, Lillian Russo-Savage, Yasaman Bahojb Habibyan, Catherine M Keenan, Laurie E Wallace, Yasmin Nasser, Gary M Mawe, Brigitte Lavoie, Keith A Sharkey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Timothy D RothHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Lillian Russo-SavageDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Yasaman Bahojb HabibyanHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Catherine M KeenanHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Laurie E WallaceHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Yasmin NasserSnyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-2081-0348
Gary M MaweDepartment of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Brigitte LavoieDepartment of Neurological Sciences, University of Vermont, Burlington, Vermont, United States.ORCID 0000-0003-3746-2578
Keith A SharkeyHotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-9560-1711

Funding

Autoimmune mechanisms of gastrointestinal dysmotility in multiple sclerosisR01DK113800 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MAWE, GARY M · 2017 to 2020
$1.8M
Use of tryptophan-synthesizing bacteria to enhance intestinal motilityR21AT011203 · NCCIH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LAVOIE, BRIGITTE · 2021 to 2022
$421k
Canadian Institutes of Health Research (CIHR) FDN148380HHS | National Institutes of Health (NIH) AT011203HHS | National Institutes of Health (NIH) DK113800NCCIH NIH HHS R21 AT011203NIDDK NIH HHS R01 DK113800
6 · The paper itself

Abstract

Serotonin (5-HT) is a multifunctional signaling molecule in the gastrointestinal (GI) tract. 5-HT synthesis is regulated by the gut microbiota. Microbial dysbiosis has been implicated in visceral pain and persistent alterations in gut function that occur following inflammation. Here, we tested the hypothesis that alterations in gut microbiota in a postinflammatory model of visceral pain contribute to dysregulated 5-HT signaling. We used mice treated with dextran sodium sulfate (DSS) 42 days earlier (postcolitis) or untreated mice as donors for fecal microbiota transplants (FMTs) into germ-free mice to explore changes in enterochromaffin (EC) cell populations, expression of 5-HT synthesis, transport, and degradation genes, levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and 5-HT release. Significant differences were observed in EC cells,

Indexed as

ColitisDysbiosisGastrointestinal MicrobiomeSerotoninVisceral PainAnimalsColonDextran SulfateDisease Models, AnimalEnterochromaffin CellsFecal Microbiota TransplantationHydroxyindoleacetic AcidMaleMiceMice, Inbred C57BLSerotonin Plasma Membrane Transport ProteinsDextran SulfateHydroxyindoleacetic AcidSerotoninSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseTph1 protein, mouseTryptophan HydroxylaseDSS colitisenterochromaffin cellsgut microbiomeinflammationinflammatory bowel disease

Identifiers

PMID41343181
PMCPMC12797318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.