ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Natural history and outcomes of medically treated coronary artery disease: insights from reconstructed individual patient data of 29 randomized trials.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Body composition phenotypes are key predictors of cardiovascular-kidney-metabolic multimorbidity and long-term mortality: insights from a population-based cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023.EClinicalMedicine · 2026Article
- Article
- Systematic review of cardiovascular care delivery across health systems in the Asia-Pacific: a regional roadmap for strengthening cardiovascular care.The Lancet regional health. Western Pacific · 2026Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
backgroundThe natural history of medically treated chronic CAD remains unclear. The current study pools evidence from randomized controlled trials to examine the natural progression and long-term outcomes in the population with chronic CAD.
methodsMedline, Embase, and Cochrane databases were searched in March 2024 to identify relevant randomized-controlled trials (RCTs) reporting long-term outcomes for chronic CAD individuals on guideline-directed medical therapy (GDMT). A single-arm meta-analysis of proportions and means was performed on the baseline characteristics, primary and secondary endpoints. Individual patient data were reconstructed from Kaplan-Meier estimates published in the included RCTs for all-cause mortality and myocardial infarction (MI).
resultsA total of 29 trials, comprising 51,275 individuals with medically treated chronic CAD, were included. The pooled incidence rates for all-cause mortality, MI and cardiac death were 19.3 (95%CI, 18.0-20.7), 30.0 (95%CI, 27.6-32.6), and 8.6 (95%CI, 5.8-12.7) per 1000 person-years, respectively. Incremental risks in all-cause mortality and MI in chronic CAD were observed across time, at one (0.8% and 2.6%), two (2.0% and 2.3%), three (3.3% and 7.5%), four (4.9% and 5.0%) and five years (10.5% and 8.4%), respectively. The rates of angina and coronary revascularization were 76.1 (95%CI, 31.6 to 183.4) and 37.3 (95%CI, 25.1 to 55.2) events per 1000 person-years.
conclusionThe reconstructed individual patient data meta-analysis of patients with chronic CAD over 185,455 person-years highlights that the natural progression of chronic CAD is far from stable, with cardiovascular risks more than doubling at ≥ 5 years of follow-up.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.