ArticleAnnals of nuclear medicine2026
Preoperative diagnostic accuracy of thyroid follicular carcinoma using fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography and blood data.
Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Effect of magnetic resonance image-based motion correction on the centiloid scale: a comparison with and without correction.Annals of nuclear medicine · 2026Article
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10 authors.
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Abstract
objectiveTo evaluate the diagnostic accuracy of fluorine-18-fluorodeoxyglucose-positron emission tomography (
methodsWe analyzed 53 patients (12, 10, and 31 with follicular cancer, follicular adenoma, and adenomatous goiter, respectively) selected from 12,403 consecutive patients who underwent preoperative
resultsSignificant differences were observed between the two groups regarding calcification, SUVmax, SUVmax/tumor size, and thyroglobulin levels (all p < 0.01). Peripheral calcification was more common in follicular carcinomas (6/12 cases) than in benign thyroid tumors (1/41 cases). The area under the ROC curve (AUC) was 0.89 for SUVmax, with a Youden index cut-off value of 5.2, yielding 100% sensitivity and 73.2% specificity. For thyroglobulin, the AUC was 0.739, with a Youden index cut-off value of 3379, resulting in 58.3% sensitivity and 87.8% specificity. Only 2.4% of benign thyroid tumors were positive for all three indicators (SUVmax > 5.2, presence of tumor calcification, and thyroglobulin > 3379), whereas 50% of follicular carcinomas were positive for all indicators, corresponding to a sensitivity and specificity for malignancy of 50% and 97.6%, respectively. Notably, no case of follicular carcinoma presented with all three indicators negative or SUVmax < 5.2 (100% specificity).
conclusionsThe combination of high SUVmax, CT-detected calcification, and high thyroglobulin levels strongly suggests follicular carcinoma and may warrant resection.
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