Evidence map›Paper›PMID 41343005›Full record

ArticleArchives of sexual behavior2025

Effect of Medical Interventions on Body Satisfaction in Gender-Dysphoric Adolescents.

Camille Ammann, Lukasz Smigielski, Manuela Lutz, Tanja Schenker, Verena Riedo, Nicole Besse-Flütsch, Isabelle Häberling, Susanne Walitza, Dagmar Pauli

Abstract read
In one paragraph

Article in Archives of sexual behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Camille AmmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland. camille.ammann@uzh.ch.ORCID http://orcid.org/0000-0001-5076-9131
Lukasz SmigielskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Manuela LutzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Tanja SchenkerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Verena RiedoDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Nicole Besse-FlütschDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Isabelle HäberlingDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.
Dagmar PauliDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Neumünsterallee 9, 8032, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Body dissatisfaction contributes to distress in gender dysphoria, but longitudinal evidence on factors alleviating this discomfort is limited. This naturalistic study examined the effect of gender-affirming hormone therapy (GAHT) alone and in combination with gender-affirming surgery (GAHT + GAS) on body satisfaction. Eighty-two adolescents (mean age, 15.77 ± 1.37) referred to a specialist clinic were examined at two time points and classified into three groups at follow-up (mean interval, 1.93 ± 0.72 years): (1) no medical interventions or puberty blocking (n = 15; counts of birth-assigned females and males: 11F/4M); (2) GAHT (n = 40; 28F/12M); and (3) GAHT + GAS (n = 27; 26F/1M). Group-level changes in Body Image Scale over time, nonmedical predictors, and associations between different facets of body dissatisfaction and life satisfaction were examined. Compared to the no-intervention/puberty blocking group, adolescents showed significantly reduced body dissatisfaction after gender-affirming interventions with no statistically significant difference between the GAHT and GAHT + GAS groups. Although there were no predictors of change in body dissatisfaction, social transitioning and satisfying family functioning at baseline were associated with lower body dissatisfaction at follow-up. Body dissatisfaction and life satisfaction were negatively correlated. These results suggest gender-affirming interventions can alleviate body dissatisfaction, at least in the short term. Moreover, social transitioning and family support were factors linked to body satisfaction. Future research should further investigate the benefit-risk profile of gender-affirming interventions in the psycho-functional and somatic domains, applying more robust study designs that minimize selection and response bias, with longer observation periods and larger sample sizes.

Indexed as

Body DissatisfactionBody ImageGender-Affirming SurgeryGender DysphoriaPersonal SatisfactionAdolescentBody SatisfactionFemaleHumansMaleAdolescentsBody imageBody satisfactionGender-affirming hormonesGender-affirming surgeryGender dysphoria

Identifiers

PMID41343005
PMCPMC12753545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.