ArticleDiscover oncology2025
Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
backgroundStomach cancer, or gastric cancer (GC), is a major global health problem characterized by the malignant proliferation of cells in the gastrointestinal lining. Recent studies have highlighted the potential therapeutic effects of natural compounds, including baicalein (BC), a flavonoid derived from the roots of Scutellaria baicalensis. This systematic review aims to evaluate the effects and mechanisms of action of BC in stomach cancer.
methodThe study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was performed in PubMed, Embase, Web of Science, and Scopus databases up to March 2025.
resultsThe review demonstrated that BC exerts therapeutic effects on GC through multiple biochemical mechanisms. BC plays an important role in inducing apoptosis, inhibiting cell proliferation, and suppressing metastasis in GC cells. It also modulates several signaling pathways, including phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinases (MAPKs), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), leading to the downregulation of oncogenes.
conclusionGiven its effects on GC progression, BC may serve as a potential adjuvant therapy. However, to confirm its clinical benefits, well-designed human studies in GC patients are required.
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