Evidence map›Paper›PMID 41342981›Full record

ReviewCancer metastasis reviews2025

Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact.

Sreedevi Damodaran, Chameera Ekanayake Weeramange, Lizbeth Kenny, Sarju Vasani, Brett G M Hughes, Omar Breik, Chamindie Punyadeera

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sreedevi DamodaranSaliva & Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Chameera Ekanayake WeeramangeSaliva & Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Lizbeth KennySchool of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Sarju VasaniSaliva & Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Brett G M HughesSchool of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Omar BreikSaliva & Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia.
Chamindie PunyadeeraSaliva & Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics, Griffith University, Nathan, Queensland, Australia. c.punyadeera@griffith.edu.au.

Funding

National Health and Medical Research Council 2012560
6 · The paper itself

Abstract

Head and neck squamous cell cancers (HNSCC) are a clinically and biologically diverse group of malignancies with limited tools for real-time monitoring and early detection of recurrence. Liquid biopsy strategies-particularly the analysis of circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA)-have emerged as promising, minimally invasive biomarkers to capture real-time tumour dynamics. This review explores cellular and molecular processes that facilitate the release and survival of CTCs and ctDNA in the circulation in HNSCC. We also address the clinical relevance of CTCs and ctDNA in the prognosis, treatment response, and detection of minimal residual disease in HNSCC. Although integrating liquid biopsies into clinical care is limited by lack of standardisation, biological variability, and workflow challenges, CTCs and ctDNA have great potential to revolutionise HNSCC patient care with real-time and tailored interventions.

Indexed as

Biomarkers, TumorCirculating Tumor DNAHead and Neck NeoplasmsNeoplastic Cells, CirculatingHumansLiquid BiopsyPrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorCirculating Tumor DNABiomarkersCirculating tumour cellsCirculating tumour DNAHead and neck cancerLiquid biopsyMinimal residual diseasePrecision oncology

Identifiers

PMID41342981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.