ReviewDiscover oncology2025
Surgical intervention strategies for tumor microenvironment (TME) associated therapeutic resistance.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between preoperative inflammatory biomarkers and postoperative pulmonary complications in stage I-II non-small cell lung cancer: a retrospective study.Frontiers in medicine · 2026Article
- Perioperative local anesthetics as modulators of tumor progression and metastasis.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The tumor microenvironment (TME) drives therapeutic resistance through immunosuppression, stromal remodeling, and metabolic reprogramming, which pose a major challenge in solid tumor treatment. While surgery remains a cornerstone for tumor eradication, perioperative inflammatory responses and ischemia-reperfusion injuries may exacerbate TME deterioration. However, surgery also offers a strategic opportunity for TME modulation. This narrative review analyzes TME components and resistance mechanisms, proposing a multi-stage intervention framework: preoperative TME reshaping, intraoperative precision resection with local therapy, and postoperative dynamic monitoring. We further explore a multidisciplinary whole-course management model, integrating cutting-edge technologies such as radiomics and single-cell sequencing. By bridging basic research with clinical translation, this review aims to guide surgeons in transitioning from tumor resection to TME precision regulation, with a focus on perioperative multi-stage interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.