Evidence map›Paper›PMID 41342952›Full record

Trial reportWorld journal of urology2025

Randomized trial of unilateral versus bilateral percutaneous tibial nerve stimulation for the treatment of overactive bladder.

Gnankang Sarah Napoé, Evelyn Hall, Pritika Dasgupta, Deborah L Myers, Kyle J Wohlrab

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03535857 (Effectiveness of Bilateral PTNS Compared to Unilateral PTNS for the Treatment of Overactive Bladder/Urge Incontinence), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03535857 naterminatednot on this map

Effectiveness of Bilateral PTNS Compared to Unilateral PTNS for the Treatment of Overactive Bladder/Urge Incontinence

TypeinterventionalSponsorGnankang Sarah NapoeRan2018 to 2023Enrolled36ConditionsOveractive Bladder Syndrome, Urinary Incontinence, UrgeArmsPTNS
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gnankang Sarah NapoéDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. sarahnapoe@pitt.edu.ORCID http://orcid.org/0000-0001-9734-0527
Evelyn HallDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, USA.
Pritika DasguptaMagee-Womens Research Institute, Pittsburgh, PA, USA.
Deborah L MyersDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Brown University, Providence, RI, USA.
Kyle J WohlrabDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women & Infants Hospital of Rhode Island, Brown University, Providence, RI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOptimizing overactive bladder (OAB) management has the potential to improve quality of life. We sought to determine whether bilateral was more effective than unilateral Percutaneuous Tibial Nerve Stimulation (PTNS) at improving OAB symptoms.

methodsParticipants were randomized to either bilateral or unilateral PTNS and followed for 12 weeks. OAB questionnaire short form (OABqSF) and Incontinence Impact questionnaire (IIQ) were administered at baseline and every 4 weeks through week 12. Participants also completed a 2-day voiding diary weekly. Our primary outcome was change in OABqSF from baseline to completion of study. Secondary outcomes included change in IIQ, number of daily voids, nocturia and incontinence episodes. Score changes were compared using ANOVA and pairwise t-test.

resultsWe randomized 36 women, mean age 68.7 (range 32-90) years. Overall, baseline OABqSF and IIQ scores were similar between the groups. Both groups showed significant improvement in OABqSF over time. 55.6% of participants in the unilateral group and 66.7% of participants in the bilateral group had improvement per OABqSF scores. While both groups showed improvement in IIQ, only the bilateral group's improvement was statistically significant. Although, the mean and median differences in OABqSF, IIQ, and incontinence episodes were lower in the bilateral group, the difference between the groups was not significant.

conclusionBoth unilateral and bilateral PTNS led to significant decreases in OABqSF with a trend for more improvement in the bilateral group. IIQ score only improved in the bilateral group suggesting a potential benefit from bilateral use.

trial registrationThe trial was registered on clinicaltrials.gov, NCT03535857.

Indexed as

Tibial NerveTranscutaneous Electric Nerve StimulationUrinary Bladder, OveractiveAdultAgedAged, 80 and overFemaleHumansMiddle AgedQuality of LifeTreatment OutcomeBilateral PTNSOveractive bladderPercutaneous tibial nerve stimulationUrge urinary incontinence

Identifiers

PMID41342952

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.