Evidence map›Paper›PMID 41342950›Full record

ReviewDiscover oncology2025

The functions of circular RNAs and long noncoding RNAs in cholangiocarcinoma.

Zhangdi Yan, Lixin Du, Xiaotong Zhang, Yunjia Liu, Yuankun Zhang, Jian Deng, Zongli Zhang, Yongchang Tang

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhangdi Yan *Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Lixin Du *Department of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Xiaotong ZhangDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Yunjia LiuDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Yuankun ZhangDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Jian DengDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China.
Zongli ZhangDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China. zzlzzl1900@163.com.
Yongchang TangDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China. tangyongchang@sdu.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2023QH535Shandong Province Key Research and Development Project 2021CXGC011105
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a highly aggressive malignancy with an extremely poor prognosis. The rising incidence of cholangiocarcinoma in recent years underscores the need for new diagnostic biomarkers and therapeutic targets. Circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) have become important research focuses in oncology, including in CCA. The specific expression patterns of circRNAs and lncRNAs has been associated with unfavorable clinicopathological features in CCA. CircRNAs and lncRNAs play crucial roles in the occurrence, development, and drug resistance of CCA through various mechanisms. This review primarily focuses on exploring the biological roles and pathways of these non-coding RNAs in CCA. Additionally, we examine the practical implications and feasibility of using circRNAs and lncRNAs as diagnostic and prognostic markers, while also exploring their potential as therapeutic targets for CCA.

Indexed as

BiomarkersCholangiocarcinomaCircRNAsLncRNAsTherapeutic targets

Identifiers

PMID41342950
PMCPMC12779888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.