Evidence map›Paper›PMID 41342934›Full record

ArticleEuropean journal of nutrition2025

The gut microbiome mediates the association between a flavonoid-rich diet and MASLD in a population-level analysis.

William Bell, Amy Jennings, Nicola P Bondonno, Andre Franke, Corinna Bang, Marcus Both, Jan Kassubek, Hans-Peter Müller, Jan Borggrefe, Wolfgang Lieb and 2 more

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In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

William BellCo-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.
Amy JenningsCo-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.
Nicola P BondonnoCo-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK.
Andre FrankeInstitute of Clinical Molecular Biology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Corinna BangInstitute of Clinical Molecular Biology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Marcus BothDepartment of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Jan KassubekDepartment of Neurology, University of Ulm, Ulm, Germany.
Hans-Peter MüllerDepartment of Neurology, University of Ulm, Ulm, Germany.
Jan BorggrefeDepartment of Radiology, Mühlenkreiskliniken Minden, Ruhr-University Bochum, Bochum, Germany.
Wolfgang LiebInstitute of Epidemiology and Biobank PopGen, University Hospital Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Tilman Kühn *Co-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK. t.kuhn@qub.ac.uk.ORCID http://orcid.org/0000-0001-7702-317X
Aedín Cassidy *Co-Centre for Sustainable Food Systems and Institute for Global Food Security, Queen's University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK. a.cassidy@qub.ac.uk.ORCID http://orcid.org/0000-0003-0048-5602

Funding

Co-Centre for Sustainable Food Systems 22/CC/11147
6 · The paper itself

Abstract

purposeA growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome.

methodsIn a cross-sectional analysis (n = 531), using the FlavoDiet score (FDS), we assessed the association between a flavonoid-rich diet and MASLD (ascertained by magnetic resonance imaging) using multivariable logistic and linear regression. Additionally, we used mediation analysis to identify and assess potential 16S-derived gut microbiome mediators.

resultsEach doubling of the FDS was associated with a 27% lower odds of MASLD (OR: 0.73 [95% CI 0.54-0.98], p = 0.04) after multivariable adjustment. 9.2% of this association was mediated by a greater abundance of the genus Eisenbergiella (indirect effect ß = - 0.006 [95% CI - 0.019, to - 0.000], p = 0.04).

conclusionThese findings suggest that a flavonoid-rich diet is associated with better liver health, and that the abundance of the Eisenbergiella taxa may in part explain the association between a flavonoid-rich diet and MASLD.

Indexed as

DietFatty LiverFlavonoidsGastrointestinal MicrobiomeAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedFlavonoidsFlavonoidsLiverMediationMicrobiomeNAFLDNutrition

Identifiers

PMID41342934
PMCPMC12678595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.