ArticleAbdominal radiology (New York)2026
Development and validation: a whole-tumor histogram model based on intravoxel incoherent motion diffusion-weighted imaging for diagnosing tumor deposits in rectal cancer.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the value of the whole-tumor histogram model based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in diagnosing tumor deposits (TDs) in rectal cancer (RC) patients.
methodsA total of 101 RC patients, 39 TD-positive and 62 TD-negative cases, were enrolled. The whole-tumor volume was obtained by manually outlining the lesion on IVIM-DWI slices where the tumor was visible. Eighteen histogram features were extracted from the ADC, D, D*, and f maps derived from IVIM-DWI. Multivariate binary logistic regression analysis was used to develop a combined model for predicting TD status. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis and the area under the ROC curve (AUC). Internal validation was performed to evaluate model performance.
resultsADC energy, ADC total energy, D energy, D kurtosis, D maximum, D range, D total energy, D* maximum, D* mean, D* range, D* mean absolute deviation, D* root mean squared, D* variance, f energy, and f total energy differed significantly between the TD-positive and TD-negative groups. The combined model incorporating D range, D* mean absolute deviation, magnetic resonance T stage (mrT), and tumor thickness showed superior diagnostic performance for TD prediction, with an AUC of 0.854 (95% CI, 0.769-0.916), sensitivity of 0.923 (95% CI, 0.75-0.978), specificity of 0.645 (95% CI, 0.519-0.819), and accuracy of 0.752 (95% CI, 0.663-0.861). The results of internal validation indicated that the logistic regression model demonstrated good predictive performance, with an AUC of 0.841 (95% CI: 0.821-0.853), an accuracy of 0.743 (95% CI: 0.713-0.772), and sensitivity and specificity of 0.650 (95% CI: 0.487-0.795) and 0.802 (95% CI: 0.694-0.903), respectively.
conclusionWhole-tumor histogram analysis derived from IVIM-DWI provides a novel method for diagnosing TDs. The combined histogram-based model may aid the preoperative evaluation of TDs in RC patients.
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